Document Detail


Room-temperature susceptometry predicts biopsy-determined hepatic iron in patients with elevated serum ferritin.
MedLine Citation:
PMID:  22166564     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: There is an ongoing clinical need for novel methods to measure hepatic iron content (HIC) noninvasively. Both magnetic resonance imaging (MRI) and superconducting quantum interference device (SQUID) methods have previously shown promise for estimation of HIC, but these methods can be expensive and are not widely available. Room-temperature susceptometry (RTS) represents an inexpensive alternative and was previously found to be strongly correlated with HIC estimated by SQUID measurements among patients with transfusional iron overload related to thalassemia.
AIM: The goal of the current study was to examine the relationship between RTS and biochemical HIC measured in liver biopsy specimens in a more varied patient cohort.
MATERIAL AND METHODS: Susceptometry was performed in a diverse group of patients with hyperferritinemia due to hereditary hemochromatosis (HHC) (n = 2), secondary iron overload (n = 3), nonalcoholic fatty liver disease (NAFLD) (n = 2), and chronic viral hepatitis (n = 3) within one month of liver biopsy in the absence of iron depletion therapy.
RESULTS: The correlation coefficient between HIC estimated by susceptometry and by biochemical iron measurement in liver tissue was 0.71 (p = 0.022). Variance between liver iron measurement and susceptometry measurement was primarily related to reliance on the patient's body-mass index (BMI) to estimate the magnetic susceptibility of tissue overlying the liver.
CONCLUSIONS: We believe RTS holds promise for noninvasive measurement of HIC. Improved measurement techniques, including more accurate overlayer correction, may further improve the accuracy of liver susceptometry in patients with liver disease.
Authors:
Bryan D Maliken; William F Avrin; James E Nelson; Jody Mooney; Sankaran Kumar; Kris V Kowdley
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Annals of hepatology     Volume:  11     ISSN:  1665-2681     ISO Abbreviation:  Ann Hepatol     Publication Date:    2012 Jan-Feb
Date Detail:
Created Date:  2011-12-14     Completed Date:  2012-06-12     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101155885     Medline TA:  Ann Hepatol     Country:  Mexico    
Other Details:
Languages:  eng     Pagination:  77-84     Citation Subset:  IM    
Affiliation:
Center for Liver Disease, Digestive Disease Institute and Benaroya Research Institute at Virginia Mason Medical Center, Seattle, WA, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biopsy
Cohort Studies
Diagnostic Techniques and Procedures / instrumentation*
Fatty Liver / metabolism,  pathology
Female
Ferritins / blood*
Hemochromatosis / metabolism,  pathology
Hepatitis, Chronic / metabolism,  pathology
Humans
Iron / metabolism*
Iron Overload / metabolism,  pathology
Liver / metabolism*,  pathology*
Liver Cirrhosis / metabolism,  pathology
Magnetic Fields*
Male
Middle Aged
Predictive Value of Tests
Temperature*
Grant Support
ID/Acronym/Agency:
K24 DK002957/DK/NIDDK NIH HHS; K24 DK002957/DK/NIDDK NIH HHS; R21 DK072360/DK/NIDDK NIH HHS; R21 DK072360/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
7439-89-6/Iron; 9007-73-2/Ferritins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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