| Room-temperature luminescence analysis of drugs with application to the Toxi-Lab drug identification system. | |
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MedLine Citation:
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PMID: 3573728 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A method of analyzing drugs on the Toxi-Lab thin-layer chromatographic system by solid substrate room-temperature luminescence is described. Three pairs of unresolved drugs: quinine/cimetidine, caffeine/chlordiazepoxide, and phenazopyridine/lidocaine, were studied as model compounds. Their luminescence characteristics were obtained and calibration curves were found to be linear over two orders of magnitude. The effect of the nonluminescent component of each pair on the determination of the luminescent component was found to be negligible. Statistical F-tests showed that the observed differences in the slopes and intercepts of the calibration curves were due to random errors. The method was evaluated by determining quinine in urine samples at the ng level. |
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Authors:
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E B Asafu-Adjaye; S Y Su; H T Karnes |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of analytical toxicology Volume: 11 ISSN: 0146-4760 ISO Abbreviation: J Anal Toxicol Publication Date: 1987 Mar-Apr |
Date Detail:
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Created Date: 1987-06-17 Completed Date: 1987-06-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7705085 Medline TA: J Anal Toxicol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 70-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Caffeine
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analysis Calibration Chlordiazepoxide / analysis Chromatography, Thin Layer / methods* Cimetidine / analysis Lidocaine / analysis Luminescent Measurements Pharmaceutical Preparations / analysis* Phenazopyridine / analysis Quinine / analysis |
| Chemical | |
Reg. No./Substance:
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0/Pharmaceutical Preparations; 130-95-0/Quinine; 137-58-6/Lidocaine; 51481-61-9/Cimetidine; 58-08-2/Caffeine; 58-25-3/Chlordiazepoxide; 94-78-0/Phenazopyridine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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