Document Detail


Room Temperature Rh-catalyzed Asymmetric 1,4-Addition of Arylboronic Acids to Maleimides and Enones in the Presence of CF3-Substituted MeOBIPHEP Analogues.
MedLine Citation:
PMID:  21740032     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A Rh-based catalytic system implying electron-poor MeOBIPHEP analogues has been developed for the 1,4-addition of boronic acids to maleimides and enones under mild conditions at room temperature and led to succinimide derivatives and arylated cyclic ketones in good to excellent yields and ee. We uncovered the crucial role of the electronic and steric properties of diphosphine ligand and observed a strong boronic acid/ligand dependency in the case of maleimide derivatives and substrate/ligand matching in the case of cyclic enones.
Authors:
Florent Le Boucher d'Herouville; Anthony Millet; Michelangelo Scalone; Veronique Michelet
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-8
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  -     ISSN:  1520-6904     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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