| Room-air versus oxygen administration for resuscitation of preterm infants: the ROAR study. | |
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MedLine Citation:
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PMID: 21746729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We conducted a blinded, prospective, randomized control trial to determine which oxygen-titration strategy was most effective at achieving and maintaining oxygen saturations of 85% to 92% during delivery-room resuscitation. METHODS: Infants born at 32 weeks' gestation or less were resuscitated either with a static concentration of 100% oxygen (high-oxygen group) or using an oxygen-titration strategy starting from a concentration of 100% (moderate-oxygen group), or 21% oxygen (low-oxygen group). In the moderate- and low-oxygen groups, the oxygen concentration was adjusted by 20% every 15 seconds to reach a target oxygen saturation range of 85% to 92%. Treatment failure was defined as a heart rate slower than 100 beats per minute for longer than 30 seconds. RESULTS: The moderate-oxygen group spent a greater proportion of time in the target oxygen saturation range (mean: 0.21 [95% confidence interval: 0.16-0.26]) than the high-oxygen group (mean: 0.11 [95% confidence interval: 0.09-0.14]). Infants in the low-oxygen group were 8 times more likely to meet the criteria for treatment failure than those in the high-oxygen group (24% vs 3%; P = .022). The 3 groups did not differ significantly in the time to reach the target oxygen saturation range. CONCLUSIONS: Titrating from an initial oxygen concentration of 100% was more effective than giving a static concentration of 100% oxygen in maintaining preterm infants in a target oxygen saturation range. Initiating resuscitation with 21% oxygen resulted in a high treatment-failure rate. |
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Authors:
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Yacov Rabi; Nalini Singhal; Alberto Nettel-Aguirre |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2011-07-11 |
Journal Detail:
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Title: Pediatrics Volume: 128 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-02 Completed Date: 2011-10-13 Revised Date: 2012-01-12 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
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Languages: eng Pagination: e374-81 Citation Subset: AIM; IM |
Affiliation:
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Division of Neonatology, Department of Pediatrics, University of Calgary, Calgary, Alberta, Canada. jack.rabi@albertahealthservices.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Air* Dose-Response Relationship, Drug Female Humans Infant, Newborn Infant, Premature Male Oxygen / administration & dosage* Oxygen Inhalation Therapy / methods* Prospective Studies Resuscitation / methods* Single-Blind Method Treatment Failure |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
| Comments/Corrections | |
Erratum In:
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Pediatrics. 2011 Dec;128(6):1212 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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