Document Detail

Room-air versus oxygen administration for resuscitation of preterm infants: the ROAR study.
MedLine Citation:
PMID:  21746729     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We conducted a blinded, prospective, randomized control trial to determine which oxygen-titration strategy was most effective at achieving and maintaining oxygen saturations of 85% to 92% during delivery-room resuscitation.
METHODS: Infants born at 32 weeks' gestation or less were resuscitated either with a static concentration of 100% oxygen (high-oxygen group) or using an oxygen-titration strategy starting from a concentration of 100% (moderate-oxygen group), or 21% oxygen (low-oxygen group). In the moderate- and low-oxygen groups, the oxygen concentration was adjusted by 20% every 15 seconds to reach a target oxygen saturation range of 85% to 92%. Treatment failure was defined as a heart rate slower than 100 beats per minute for longer than 30 seconds.
RESULTS: The moderate-oxygen group spent a greater proportion of time in the target oxygen saturation range (mean: 0.21 [95% confidence interval: 0.16-0.26]) than the high-oxygen group (mean: 0.11 [95% confidence interval: 0.09-0.14]). Infants in the low-oxygen group were 8 times more likely to meet the criteria for treatment failure than those in the high-oxygen group (24% vs 3%; P = .022). The 3 groups did not differ significantly in the time to reach the target oxygen saturation range.
CONCLUSIONS: Titrating from an initial oxygen concentration of 100% was more effective than giving a static concentration of 100% oxygen in maintaining preterm infants in a target oxygen saturation range. Initiating resuscitation with 21% oxygen resulted in a high treatment-failure rate.
Yacov Rabi; Nalini Singhal; Alberto Nettel-Aguirre
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2011-07-11
Journal Detail:
Title:  Pediatrics     Volume:  128     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-02     Completed Date:  2011-10-13     Revised Date:  2012-01-12    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e374-81     Citation Subset:  AIM; IM    
Division of Neonatology, Department of Pediatrics, University of Calgary, Calgary, Alberta, Canada.
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MeSH Terms
Dose-Response Relationship, Drug
Infant, Newborn
Infant, Premature
Oxygen / administration & dosage*
Oxygen Inhalation Therapy / methods*
Prospective Studies
Resuscitation / methods*
Single-Blind Method
Treatment Failure
Reg. No./Substance:
Erratum In:
Pediatrics. 2011 Dec;128(6):1212

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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