| Roles of reproductive corticotropin-releasing hormone. | |
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MedLine Citation:
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PMID: 14644819 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Corticotropin-releasing hormone (CRH), the principal regulator of the hypothalamic-pituitary-adrenal axis, as well as its receptors, have been identified in most female reproductive tissues, including the uterus, placenta, and ovary. Endometrial CRH may participate in decidualization, implantation, and early maternal tolerance; placental CRH may participate in the physiology of pregnancy and the onset of parturition, and ovarian CRH may participate in follicular maturation, ovulation, and luteolysis. The hypercortisolism of the latter half of pregnancy can be explained by increased levels of placental CRH in plasma. This hypercortisolism is followed by a transient suppression of hypothalamic CRH secretion in the postpartum period, which may explain the blues or depression and autoimmune phenomena frequently observed during this period. |
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Authors:
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Sophia N Kalantaridou; Antonis Makrigiannakis; George Mastorakos; George P Chrousos |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 997 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-12-03 Completed Date: 2004-01-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 129-35 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Ioannina Medical School, University Hospital, Panepistimiou Avenue, 45500 Ioannina, Greece. kalantas@exchange.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Corticotropin-Releasing Hormone / metabolism* Embryo Implantation Female Humans Hypothalamo-Hypophyseal System / physiology Menstrual Cycle / physiology Parturition / physiology* Pituitary-Adrenal System / physiology* Pregnancy Pregnancy, Animal Rats Reproduction / physiology* Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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