| Roles of pancreatic polypeptide in regulation of food intake. | |
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MedLine Citation:
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PMID: 11825646 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pancreatic polypeptide (PP) is produced in pancreatic islets of Langerhans and released into the circulation after ingestion of a meal. Peripherally administered PP suppresses food intake and gastric emptying. On the other hand, central administration of PP elicits food intake and gastric emptying. Therefore, PP actions on food intake may be, in part, attributable to gastric emptying. PP transgenic mice exhibit decreases in both food intake and gastric emptying rate that were clearly reversed by anti-PP antiserum. PP is an anorexigenic signal in the periphery and an orexigenic signal in the central nervous system. |
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Authors:
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Goro Katsuura; Akihiro Asakawa; Akio Inui |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Peptides Volume: 23 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-02-04 Completed Date: 2002-05-06 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: United States |
Other Details:
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Languages: eng Pagination: 323-9 Citation Subset: IM |
Affiliation:
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Aburahi Laboratories, Shionogi & Co. Ltd., Shiga, 520-3423 Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Central Nervous System / metabolism Dose-Response Relationship, Drug Feeding Behavior / drug effects Gastric Emptying / drug effects* Mice Mice, Transgenic Pancreatic Polypeptide / metabolism*, physiology* Time Factors |
| Chemical | |
Reg. No./Substance:
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59763-91-6/Pancreatic Polypeptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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