Document Detail

Roles of pancreatic polypeptide in regulation of food intake.
MedLine Citation:
PMID:  11825646     Owner:  NLM     Status:  MEDLINE    
Pancreatic polypeptide (PP) is produced in pancreatic islets of Langerhans and released into the circulation after ingestion of a meal. Peripherally administered PP suppresses food intake and gastric emptying. On the other hand, central administration of PP elicits food intake and gastric emptying. Therefore, PP actions on food intake may be, in part, attributable to gastric emptying. PP transgenic mice exhibit decreases in both food intake and gastric emptying rate that were clearly reversed by anti-PP antiserum. PP is an anorexigenic signal in the periphery and an orexigenic signal in the central nervous system.
Goro Katsuura; Akihiro Asakawa; Akio Inui
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Peptides     Volume:  23     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-04     Completed Date:  2002-05-06     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  323-9     Citation Subset:  IM    
Aburahi Laboratories, Shionogi & Co. Ltd., Shiga, 520-3423 Japan.
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MeSH Terms
Central Nervous System / metabolism
Dose-Response Relationship, Drug
Feeding Behavior / drug effects
Gastric Emptying / drug effects*
Mice, Transgenic
Pancreatic Polypeptide / metabolism*,  physiology*
Time Factors
Reg. No./Substance:
59763-91-6/Pancreatic Polypeptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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