| Roles of milk fat globule-epidermal growth factor 8 in intestinal inflammation. | |
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MedLine Citation:
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PMID: 22269288 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Milk fat globule-epidermal growth factor 8 (MFG-E8), a glycoprotein secreted from various cells, enhances engulfment of apoptotic cells by forming a link between phosphatidylserine on apoptotic cells and α(v)β(3)-integrin on phagocytes. This process is essential for maintaining the host immune system under physiological conditions. Apart from this scavenging function, MFG-E8 also directly regulates a variety of cellular functions, such as attenuating inflammation and healing of injured tissues. Furthermore, recent studies have revealed that MFG-E8 has anti-inflammatory and regenerating roles during intestinal inflammation. This review highlights novel findings regarding the roles of MFG-E8 in intestinal pathophysiology as well as its therapeutic potential for gut inflammatory disorders. |
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Authors:
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Ryusaku Kusunoki; Shunji Ishihara; Monowar Aziz; Akihiko Oka; Yasumasa Tada; Yoshikazu Kinoshita |
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Publication Detail:
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Type: Journal Article Date: 2012-01-19 |
Journal Detail:
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Title: Digestion Volume: 85 ISSN: 1421-9867 ISO Abbreviation: Digestion Publication Date: 2012 |
Date Detail:
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Created Date: 2012-01-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0150472 Medline TA: Digestion Country: Switzerland |
Other Details:
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Languages: eng Pagination: 103-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 S. Karger AG, Basel. |
Affiliation:
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Department of Internal Medicine II, Shimane University School of Medicine, Izumo, Japan. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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