Document Detail


Roles of levo-tetrahydropalmatine in modulating methamphetamine reward behavior.
MedLine Citation:
PMID:  23711566     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Levo-tetrahydropalmatine (l-THP), as an alkaloid purified from the traditional Chinese herbal medicine Corydalis and Stephania, has been widely used to produce many traditional Chinese herbal preparations. The effect of l-THP on methamphetamine-induced reward learning still remains unclear although it has been proved to be effective on treating allodynia and drug addiction. This experiment has been designed to examine the effect of l-THP on the acquisition, expression, extinction, and reinstatement of methamphetamine-induced conditioned place preference (CPP) in mice. The results show that methamphetamine (METH) could induce CPP in mice at doses of 0.5mg/kg, 1.0mg/kg and 2.0mg/kg respectively, but l-THP alone could not do so. Meanwhile, l-THP could not induce conditioned place aversion at doses of 1.25mg/kg to 20.0mg/kg in mice, but it could attenuate the acquisition and expression of METH-induced CPP and facilitate the extinction of METH-induced CPP in mice. Besides, l-THP could inhibit the reinstatement of METH-induced CPP at the dose of 10.0mg/kg whether it was given in the extinction training phase or 30min before the reinstatement. These results suggest that l-THP can globally suppress the rewarding properties of METH on all phases of the CPP task and it may have potential effects on the treatment of METH abuse.
Authors:
Hong-Liang Su; Jie Zhu; Yan-Jiong Chen; Na Zhao; Wei Han; Yong-Hui Dang; Ming Xu; Teng Chen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-05-25
Journal Detail:
Title:  Physiology & behavior     Volume:  118     ISSN:  1873-507X     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-07-22     Completed Date:  2014-02-12     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  195-200     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Avoidance Learning / drug effects
Berberine Alkaloids / pharmacology*
Central Nervous System Stimulants / antagonists & inhibitors*,  pharmacology*
Conditioning, Operant / drug effects*
Corydalis / chemistry
Data Interpretation, Statistical
Dopamine Antagonists / pharmacology*
Dose-Response Relationship, Drug
Extinction, Psychological / drug effects
Learning / drug effects
Male
Methamphetamine / antagonists & inhibitors*,  pharmacology*
Mice
Mice, Inbred C57BL
Reward*
Stephania / chemistry
Grant Support
ID/Acronym/Agency:
DA025088/DA/NIDA NIH HHS; DA17323/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Berberine Alkaloids; 0/Central Nervous System Stimulants; 0/Dopamine Antagonists; 10097-84-4/tetrahydropalmatine; 44RAL3456C/Methamphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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