| Roles of ischemia and hypoxia and the molecular pathogenesis of post-burn cardiac shock. | |
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MedLine Citation:
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PMID: 14636759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the roles of ischemia and hypoxia in the development of post-burn cardiac shock and its molecular pathogenesis. METHODS: One hundred and fifty healthy adult Wistar rats were divided into the control group and burn group inflicted with 30% total body surface area third degree burn. Groups were processed at 1, 3, 6, 12 and 24h post-burn. Myocardial contractile function, myocardial microvascular permeability, volume of regional myocardial blood flow, levels of myocardial myosin light chain 1 (CM-LC1), myocardial NF-kappaB (nuclear factor kappa B) activity, MPO (myeloperoxidase), TNFalpha (tumor necrosis factor alpha) mRNA expression and levels of myocardial TNFalpha were measured. MAIN RESULTS: Myocardial microvascular permeability began to rise at 1h post-burn and was still rising at 24h (2.1 times as high as that of the control group); the volume of regional myocardial blood flow fell significantly and remained at a level markedly lower than that in the control group; CM-LC1 also rose significantly and reached a level 18.6 times as high as that in the control group; myocardial NF-kappaB activity and TNFalpha mRNA expression were significantly promoted; elevation of levels of myocardial TNFalpha and MPO activity occurred; cardiac mechanic parameters including LVSP, +/-dp/dt max significantly decreased while LVEDP increased. CONCLUSION: The findings of the present study suggest severe myocardial damage due to ischemia and hypoxia following burns; promotion of myocardial NF-kappaB activity and TNFalpha mRNA expression in myocardium may be an important factor in the development of post-burn cardiac shock. |
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Authors:
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Yuesheng Huang; Zhiqing Li; Zongcheng Yang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Burns : journal of the International Society for Burn Injuries Volume: 29 ISSN: 0305-4179 ISO Abbreviation: Burns Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2003-11-25 Completed Date: 2004-03-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8913178 Medline TA: Burns Country: England |
Other Details:
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Languages: eng Pagination: 828-33 Citation Subset: IM |
Affiliation:
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Institute of Burn Research, Southwestern Hospital, Third Military Medical University, 400038, Chongqing, PR China. yshuang@public.cta.cq.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / complications*, metabolism, physiopathology Burns / complications*, metabolism, physiopathology Capillary Permeability Coronary Circulation Myocardial Contraction Myocardial Ischemia / complications*, metabolism, physiopathology Myocardium / metabolism Myosin Light Chains / analysis NF-kappa B / analysis Peroxidase / analysis RNA, Messenger / analysis Rats Rats, Wistar Regional Blood Flow Shock, Cardiogenic / etiology*, metabolism, physiopathology Time Factors Tumor Necrosis Factor-alpha / analysis, genetics |
| Chemical | |
Reg. No./Substance:
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0/Myosin Light Chains; 0/NF-kappa B; 0/RNA, Messenger; 0/Tumor Necrosis Factor-alpha; EC 1.11.1.7/Peroxidase |
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