Document Detail


Roles of insulin-like growth factor binding protein-2 (IGFBP-2) in glioblastoma.
MedLine Citation:
PMID:  17970029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Insulin-like growth factor binding protein-2 (IGFBP-2) is reported to be a modulator of the action of insulin-like growth factors (IGFs), whereas IGF-independent effects of IGFBP-2 on cellular proliferation, apoptosis, and mobility have been revealed not only during the embryonic state but also in the pathological state of cancer. As well as other types of carcinomas, overexpression of IGFBP-2 has been reported in glioblastoma multiforme (GBM), the most malignant brain tumor characterized by rapid growth, extensive invasiveness, and angiogenesis. However, it remains unclear how IGFBP-2 is involved in the malignant features of GBM. This review outlines the IGF-dependent and -independent functions of IGFBP-2 and focuses on the roles of IGFBP-2 in the progression of GBM.
Authors:
Tsuyoshi Fukushima; Hiroaki Kataoka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Anticancer research     Volume:  27     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    2007 Nov-Dec
Date Detail:
Created Date:  2007-10-31     Completed Date:  2007-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  3685-92     Citation Subset:  IM    
Affiliation:
Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
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MeSH Terms
Descriptor/Qualifier:
Brain Neoplasms / blood supply,  metabolism*
Cell Proliferation
Disease Progression
Glioblastoma / blood supply,  metabolism*
Humans
Insulin-Like Growth Factor Binding Protein 2 / physiology*
Models, Biological
Neovascularization, Pathologic
Signal Transduction
Somatomedins / metabolism
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Insulin-Like Growth Factor Binding Protein 2; 0/Somatomedins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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