| Roles of insulin-like growth factor binding protein-2 (IGFBP-2) in glioblastoma. | |
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MedLine Citation:
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PMID: 17970029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Insulin-like growth factor binding protein-2 (IGFBP-2) is reported to be a modulator of the action of insulin-like growth factors (IGFs), whereas IGF-independent effects of IGFBP-2 on cellular proliferation, apoptosis, and mobility have been revealed not only during the embryonic state but also in the pathological state of cancer. As well as other types of carcinomas, overexpression of IGFBP-2 has been reported in glioblastoma multiforme (GBM), the most malignant brain tumor characterized by rapid growth, extensive invasiveness, and angiogenesis. However, it remains unclear how IGFBP-2 is involved in the malignant features of GBM. This review outlines the IGF-dependent and -independent functions of IGFBP-2 and focuses on the roles of IGFBP-2 in the progression of GBM. |
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Authors:
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Tsuyoshi Fukushima; Hiroaki Kataoka |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Anticancer research Volume: 27 ISSN: 0250-7005 ISO Abbreviation: Anticancer Res. Publication Date: 2007 Nov-Dec |
Date Detail:
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Created Date: 2007-10-31 Completed Date: 2007-12-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 3685-92 Citation Subset: IM |
Affiliation:
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Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brain Neoplasms
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blood supply,
metabolism* Cell Proliferation Disease Progression Glioblastoma / blood supply, metabolism* Humans Insulin-Like Growth Factor Binding Protein 2 / physiology* Models, Biological Neovascularization, Pathologic Signal Transduction Somatomedins / metabolism Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Insulin-Like Growth Factor Binding Protein 2; 0/Somatomedins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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