Document Detail


Roles of heme oxygenase/carbon monoxide system in genetically hypertensive rats.
MedLine Citation:
PMID:  9425313     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although carbon monoxide (CO) has been suggested to be involved in the regulation of cardiovascular function through activation of soluble guanylyl cyclase, the pathophysiological significance in hypertension remains unknown. We therefore examined the effects of heme oxygenase (HO) inhibitor zinc protoporphyrin IX (ZnPP-IX) on blood pressure and determined HO mRNA expression level in various tissues in stroke-prone spontaneously hypertensive rats (SHR-SP/Izm) and Wistar Kyoto rats (WKY/Izm). Although ZnPP-IX significantly increased systolic blood pressure in both strains, the increment of blood pressure was larger in SHR-SP/Izm than in WKY/Izm. An essentially similar increase of blood pressure was demonstrated even in the ganglion blocker-pretreated rats. Constitutive type HO-2 mRNA levels in the aorta and kidney and inducible type HO-1 mRNA levels in the cardiac ventricle were significantly increased in SHR-SP/Izm compared with WKY/Izm. Clearly these results indicate the importance of the endogenous HO/CO system in the peripheral tissues in genetically hypertensive rats.
Authors:
T Seki; M Naruse; K Naruse; T Yoshimoto; A Tanabe; K Tsuchiya; S Hirose; T Imaki; H Nihei; H Demura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  241     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-01-26     Completed Date:  1998-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  574-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, Tokyo Women's Medical College, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects*
Carbon Monoxide / metabolism*
Heart Rate / drug effects
Heme Oxygenase (Decyclizing) / antagonists & inhibitors,  biosynthesis*,  genetics
Hypertension / etiology,  metabolism*
Male
Protoporphyrins / pharmacology*
RNA, Messenger / analysis
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Systole
Tissue Distribution
Chemical
Reg. No./Substance:
0/Protoporphyrins; 0/RNA, Messenger; 15442-64-5/zinc protoporphyrin; 630-08-0/Carbon Monoxide; EC 1.14.99.3/Heme Oxygenase (Decyclizing)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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