| Roles of heat-shock protein 70 in protecting against intestinal mucosal damage. | |
| | |
MedLine Citation:
|
PMID: 23276928 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Heat shock proteins (HSPs) are remarkably conserved in all living organisms. The upregulation of expression of HSPs is triggered by a variety of physiological and environmental insults. HSPs play an important role in protecting against protein denaturation and subsequent celluar stress, which damages the intestinal mucosa and reduces the protective function of the mucosal barrier, resulting in the formation of stress ulcers. Heat shock protein 70 (HSP70) is the most widely studied of all HSPs and has numerous important chaperoning functions. Stress accelerates the synthesis of HSP70, which in turn inhibits the apoptosis of intestinal mucosal cells. In this article, we review the main classification of HSPs, the expression and regulation of HSPs and their roles in stress ulcers. We also discuss the role of functional amino acids in regulating the expression of HSPs (particularly HSP70) and protecting the intestinal mucosa and other tissues. |
| | |
Authors:
|
Xi Wu; Yuzhe Zhang; Yulong Yin; Zheng Yuan; Humin Yu; Zhenlong Wu; Guoyao Wu |
Related Documents
:
|
2502108 - Immunodetectable galactosyltransferase is associated only with human spermatozoa of hig... 20375058 - Sperm equatorial segment protein 1, spesp1, is required for fully fertile sperm in mouse. 18060688 - The interaction of dnr and glutaraldehyde with cell membrane proteins leads to morpholo... 1449798 - Adsorption of oviductal fluid proteins by the bovine sperm membrane during in vitro cap... 57618 - Immunologic and fine structure evidence of avidly bound host serum proteins in the surf... 1908058 - Catabolic illness. strategies for enhancing recovery. |
Publication Detail:
|
Type: Journal Article Date: 2013-01-01 |
Journal Detail:
|
Title: Frontiers in bioscience : a journal and virtual library Volume: 18 ISSN: 1093-4715 ISO Abbreviation: Front. Biosci. Publication Date: 2013 |
Date Detail:
|
Created Date: 2013-01-01 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9709506 Medline TA: Front Biosci Country: United States |
Other Details:
|
Languages: eng Pagination: 356-65 Citation Subset: IM |
Affiliation:
|
Hunan Engineering and Research Center of Animal and Poultry Science and Key Laboratory for Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan, China 410125. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Towards elucidating the role of SirT1 in osteoarthritis.
Next Document: Prevalence and risk factor for MDR-GNB infection in liver transplantation.