Document Detail

Roles of ghrelin and leptin in the control of reproductive function.
MedLine Citation:
PMID:  17851226     Owner:  NLM     Status:  MEDLINE    
Reproductive function in mammals, defined as the capacity to generate viable male and female gametes, and to support pregnancy and lactation selectively in the female, is sensitive to the metabolic state of the organism. This contention, long assumed on the basis of intuitive knowledge, became formulated on a scientific basis only recently, with the identification of a number of neuroendocrine signals which crucially participate in the joint control of energy balance and reproduction. A paradigmatic example in this context is the adipocyte-derived hormone, leptin; a satiety factor which signals the amount of body energy (fat) stores not only to the circuits controlling food intake but also to a number of neuroendocrine axes, including the reproductive system. More recently, the reproductive dimension of another metabolic hormone, namely the orexigenic stomach-secreted peptide, ghrelin, has been disclosed by observations on its putative roles in the control of gonadal function and gonadotropin secretion. Of note, leptin and ghrelin have been proposed to act as reciprocal regulators of energy homeostasis. However, their potential interplay in the control of reproduction remains largely unexplored. Based on the comparison of the biological actions of leptin and ghrelin at different levels of the hypothalamic-pituitary-gonadal axis, reviewed in detail herein, we propose that, through concurrent or antagonistic actions, the leptin-ghrelin pair is likely to operate also as modulator of different reproductive functions, thereby contributing to the physiological integration of reproduction and energy balance.
Manuel Tena-Sempere
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-12
Journal Detail:
Title:  Neuroendocrinology     Volume:  86     ISSN:  1423-0194     ISO Abbreviation:  Neuroendocrinology     Publication Date:  2007  
Date Detail:
Created Date:  2007-11-06     Completed Date:  2007-12-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0035665     Medline TA:  Neuroendocrinology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  229-41     Citation Subset:  IM    
Copyright Information:
(c) 2007 S. Karger AG, Basel.
Physiology Section, Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain.
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MeSH Terms
Appetite Regulation / physiology
Eating / physiology
Energy Metabolism / physiology
Ghrelin / physiology*
Hypothalamo-Hypophyseal System / physiology
Leptin / physiology*
Neurosecretory Systems / physiology*
Pituitary-Adrenal System / physiology
Reproduction / physiology*
Reg. No./Substance:
0/Ghrelin; 0/Leptin

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