| Roles of dietary fat and fibre in the disposition and metabolism of carcinogens associated with foods. | |
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MedLine Citation:
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PMID: 2175719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The abilities of dietary fibre (wheat bran) or fat (olive oil) to modify the genotoxicity of radiolabelled MeIQ were evaluated in mice using in vivo and in vitro bacterial mutation assays. Bran reduced genotoxicity by restricting uptake of MeIQ from the gut lumen. In contrast, feeding mice a high fat diet led to increased hepatic conversion of MeIQ to an active genotoxin. |
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Authors:
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W E Brennan-Craddock; A J Howes; T M Coutts; I R Rowland; A J Alldrick |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Food additives and contaminants Volume: 7 Suppl 1 ISSN: 0265-203X ISO Abbreviation: Food Addit Contam Publication Date: 1990 |
Date Detail:
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Created Date: 1991-02-07 Completed Date: 1991-02-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8500474 Medline TA: Food Addit Contam Country: ENGLAND |
Other Details:
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Languages: eng Pagination: S53-4 Citation Subset: IM |
Affiliation:
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Department of Microbiology, British Industrial Biological Research Association, Carshalton, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dietary Fats / pharmacology* Dietary Fiber / pharmacology* Female Mice Mice, Inbred BALB C Mutagenicity Tests Mutagens / antagonists & inhibitors, metabolism* Quinolines / antagonists & inhibitors, metabolism*, toxicity Salmonella typhimurium / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Mutagens; 0/Quinolines; 77094-11-2/2-amino-3,4-dimethylimidazo(4,5-f)quinoline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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