Document Detail


Roles of catecholamine at the preoptic region in the regulation of cyclic ovulation and gonadotropin.
MedLine Citation:
PMID:  3120448     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Experiments were designed to see how a transplantation of newborn norepinephrine (NE) neurons from A-6 groups or dopamine (DA) neurons from A-10 groups in the third ventricle at the level of the preoptic region affected the vaginal oestrous cycle and gonadotropin secretion in the female rat. Sixty-two rats that had tissues in contact with the preoptic region were evaluated as having surviving transplants by histological examination after sacrifice. The rats that had surviving NE-neuron transplants frequently showed prolongation of oestrus during the 70-day study period, indicating that ovulation was severely impaired in these rats. However, after ovariectomy, they showed a pulsatile secretion of LH with a remarkably large amplitude. The DA-neuron transplants sustained the oestrous cycle unchanged, but increased blood levels of FSH prior to the ovulatory secretion of gonadotropin. Pulsatile LH secretion was not affected. Sham and cerebellum control rats did not show any significant changes in the oestrous cycle. The results suggest that the NE-neuron transplants at the preoptic region somehow inhibit gonadotropin secretion in intact rats, whereas they facilitate it in ovariectomized rats. The DA-neuron transplants appear to exert facilitatory effects on FSH secretion in intact rats.
Authors:
R Hashimoto; F Kimura
Related Documents :
2970368 - Histological changes in the ovary and uterus of rat after injectable contraceptive ther...
7553138 - Presence of the intermediate filaments cytokeratins and vimentin in the rat corpus lute...
15750308 - Acceleration of follicular development by administration of vascular endothelial growth...
16034198 - Induction of superovulation by immunoneutralization of endogenous inhibin in immature r...
9571158 - Defect of an early event of glucose metabolism in skeletal muscle of the male otsuka lo...
21295618 - Three-dimensional motion analysis of postural adjustments during over-ground locomotion...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta endocrinologica     Volume:  116     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1987-12-21     Completed Date:  1987-12-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  357-63     Citation Subset:  IM    
Affiliation:
2nd Department of Physiology, Yokohama City University School of Medicine, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Dopamine / physiology*
Estrus / physiology*
Female
Follicle Stimulating Hormone / secretion*
Luteinizing Hormone / secretion*
Neurons / transplantation
Norepinephrine / physiology*
Ovariectomy
Ovulation*
Preoptic Area / physiology*
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
51-41-2/Norepinephrine; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Handling of iodothyronines by the liver and kidney in patients with chronic liver disease.
Next Document:  Neuroendocrine regulation of anterior pituitary function in patients during and after molar pregnanc...