Document Detail

Roles of catecholamine at the preoptic region in the regulation of cyclic ovulation and gonadotropin.
MedLine Citation:
PMID:  3120448     Owner:  NLM     Status:  MEDLINE    
Experiments were designed to see how a transplantation of newborn norepinephrine (NE) neurons from A-6 groups or dopamine (DA) neurons from A-10 groups in the third ventricle at the level of the preoptic region affected the vaginal oestrous cycle and gonadotropin secretion in the female rat. Sixty-two rats that had tissues in contact with the preoptic region were evaluated as having surviving transplants by histological examination after sacrifice. The rats that had surviving NE-neuron transplants frequently showed prolongation of oestrus during the 70-day study period, indicating that ovulation was severely impaired in these rats. However, after ovariectomy, they showed a pulsatile secretion of LH with a remarkably large amplitude. The DA-neuron transplants sustained the oestrous cycle unchanged, but increased blood levels of FSH prior to the ovulatory secretion of gonadotropin. Pulsatile LH secretion was not affected. Sham and cerebellum control rats did not show any significant changes in the oestrous cycle. The results suggest that the NE-neuron transplants at the preoptic region somehow inhibit gonadotropin secretion in intact rats, whereas they facilitate it in ovariectomized rats. The DA-neuron transplants appear to exert facilitatory effects on FSH secretion in intact rats.
R Hashimoto; F Kimura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta endocrinologica     Volume:  116     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1987-12-21     Completed Date:  1987-12-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  357-63     Citation Subset:  IM    
2nd Department of Physiology, Yokohama City University School of Medicine, Japan.
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MeSH Terms
Dopamine / physiology*
Estrus / physiology*
Follicle Stimulating Hormone / secretion*
Luteinizing Hormone / secretion*
Neurons / transplantation
Norepinephrine / physiology*
Preoptic Area / physiology*
Rats, Inbred Strains
Reg. No./Substance:
51-41-2/Norepinephrine; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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