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Roles of TNF-α and its receptors in the beneficial effects of vagal stimulation after myocardial infarction in rats.
MedLine Citation:
PMID:  21362018     Owner:  NLM     Status:  Publisher    
Acute myocardial infarction (AMI) often activates the sympathetic system and inhibits the vagal system. Long-term vagal nerve stimulation (VNS) exerts several beneficial effects on the ischemia heart including an anti-inflammatory effect. The goal of the current study is to investigate, in a rodent model, whether short term VNS during AMI could inhibit the expression of tumor necrosis factor-alpha (TNF-α) and the effect of TNF receptor (TNFR), key components in inflammatory responses to AMI. Adult male Sprague-Dawley rats were divided into four groups: control (C), vagal nerve stimulation (S), acute myocardial infarction (M), pre-VNS(+) AMI (MS). The right vagus nerve was electrically stimulated for 4 hours. The hemodynamic data were continuously monitored by a multichannel physiologic recorder. Lactate dehydrogenase (LDH) leakage and creatine kinase (CK) as well as infarct size were measured. The expression of TNF-α and its receptor were analyzed by reverse transcription polymerase chain reaction (RT-PCR), Western blotting and enzyme-linked immunosorbent assay (ELISA). In M group, AMI rats presented low blood pressure, high left ventricular end-diastolic pressure, a depressed maximum dP/dt of left ventricular pressure, higher LDH and CK leakage and larger infarct size as well as an increased TNF-α level and increased TNFR1/TNFR2 ratio. However, these presumably harmful effects of AMI were all significantly ameliorated by VNS during AMI. In conclusion, VNS can rectify ischemia-induced cardiac dysfunction partly through an inhibitory effect of VNS on the TNF-α-mediated signaling pathway.
Shan-Shan Kong; Jin-Jun Liu; Tyzh-Chang Hwang; Xiao-Jiang Yu; Yi Lu; Wei-Jin Zang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-1
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  -     ISSN:  1440-1681     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Clinical and Experimental Pharmacology and Physiology © 2011 Blackwell Publishing Asia Pty Ltd.
Department of Pharmacology, Xi'an Jiaotong University, College of Medicine, Xi'an, PR China Department of Medical Pharmacology and Physiology, and Dalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, MO 65211, USA.
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