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Roles of TNF-α and its receptors in the beneficial effects of vagal stimulation after myocardial infarction in rats.
MedLine Citation:
PMID:  21362018     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Acute myocardial infarction (AMI) often activates the sympathetic system and inhibits the vagal system. Long-term vagal nerve stimulation (VNS) exerts several beneficial effects on the ischemia heart including an anti-inflammatory effect. The goal of the current study is to investigate, in a rodent model, whether short term VNS during AMI could inhibit the expression of tumor necrosis factor-alpha (TNF-α) and the effect of TNF receptor (TNFR), key components in inflammatory responses to AMI. Adult male Sprague-Dawley rats were divided into four groups: control (C), vagal nerve stimulation (S), acute myocardial infarction (M), pre-VNS(+) AMI (MS). The right vagus nerve was electrically stimulated for 4 hours. The hemodynamic data were continuously monitored by a multichannel physiologic recorder. Lactate dehydrogenase (LDH) leakage and creatine kinase (CK) as well as infarct size were measured. The expression of TNF-α and its receptor were analyzed by reverse transcription polymerase chain reaction (RT-PCR), Western blotting and enzyme-linked immunosorbent assay (ELISA). In M group, AMI rats presented low blood pressure, high left ventricular end-diastolic pressure, a depressed maximum dP/dt of left ventricular pressure, higher LDH and CK leakage and larger infarct size as well as an increased TNF-α level and increased TNFR1/TNFR2 ratio. However, these presumably harmful effects of AMI were all significantly ameliorated by VNS during AMI. In conclusion, VNS can rectify ischemia-induced cardiac dysfunction partly through an inhibitory effect of VNS on the TNF-α-mediated signaling pathway.
Authors:
Shan-Shan Kong; Jin-Jun Liu; Tyzh-Chang Hwang; Xiao-Jiang Yu; Yi Lu; Wei-Jin Zang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-1
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  -     ISSN:  1440-1681     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Clinical and Experimental Pharmacology and Physiology © 2011 Blackwell Publishing Asia Pty Ltd.
Affiliation:
Department of Pharmacology, Xi'an Jiaotong University, College of Medicine, Xi'an, PR China Department of Medical Pharmacology and Physiology, and Dalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, MO 65211, USA.
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