Document Detail


Roles of PI3Ks in leukocyte chemotaxis and phagocytosis.
MedLine Citation:
PMID:  11891120     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Through selective disruption of phosphoinositide 3-kinase (PI3K) activity and the use of green fluorescent protein tagged derivatives of domains capable of specifically binding the lipid products of PI3Ks in vivo, it has been shown that this family of signalling enzymes have vital and distinct roles in chemotaxis, phagocytosis and phagosome maturation in leukocytes.
Authors:
Len Stephens; Chris Ellson; Phillip Hawkins
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in cell biology     Volume:  14     ISSN:  0955-0674     ISO Abbreviation:  Curr. Opin. Cell Biol.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-03-13     Completed Date:  2002-07-26     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8913428     Medline TA:  Curr Opin Cell Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  203-13     Citation Subset:  IM    
Affiliation:
The Babraham Institute, Babraham, Cambridge CB2 4AT, UK. len.stephens@bbsrc.ac.uk
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MeSH Terms
Descriptor/Qualifier:
1-Phosphatidylinositol 3-Kinase / physiology*
Animals
Cell Polarity / physiology
Chemotactic Factors / pharmacology
Chemotaxis / physiology*
Humans
Leukocytes / cytology,  drug effects,  physiology*
Phagocytosis / physiology*
Phagosomes / physiology
Signal Transduction / physiology*
rho GTP-Binding Proteins / metabolism
Chemical
Reg. No./Substance:
0/Chemotactic Factors; EC 2.7.1.137/1-Phosphatidylinositol 3-Kinase; EC 3.6.5.2/rho GTP-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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