Document Detail


Roles for KRAS in pancreatic tumor development and progression.
MedLine Citation:
PMID:  23622131     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Kras gene is mutated to an oncogenic form in most pancreatic tumors. However, early attempts to use this molecule as a specific biomarker of the disease, or inhibit its activity as a cancer therapy, failed. This left a situation in which everyone was aware of the association between this important oncogene and pancreatic cancer, but no one knew what to do about it. Recent findings have changed this picture-many assumptions made about KRAS and its role in pancreatic cancer were found to be incorrect. Several factors have contributed to increased understanding of the activities of KRAS, including creation of genetically engineered mouse models, which have allowed for detailed analyses of pancreatic carcinogenesis in an intact animal with a competent immune system. Cancer genome sequencing projects have increased our understanding of the heterogeneity of individual tumors. We also have a better understanding of which oncogenes are important for tumor maintenance and are therefore called "drivers." We review the advances and limitations of our knowledge about the role of Kras in development of pancreatic cancers and the important areas for future research.
Authors:
Marina Pasca di Magliano; Craig D Logsdon
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Gastroenterology     Volume:  144     ISSN:  1528-0012     ISO Abbreviation:  Gastroenterology     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-04-29     Completed Date:  2013-06-20     Revised Date:  2014-04-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1220-9     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 AGA Institute. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Transformation, Neoplastic / genetics*,  metabolism,  pathology
Disease Progression
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Humans
Mutation*
Pancreatic Neoplasms / genetics*,  metabolism,  pathology,  therapy
Phenotype
Prognosis
Proto-Oncogene Proteins / genetics*,  metabolism
Signal Transduction
ras Proteins / genetics*,  metabolism
Grant Support
ID/Acronym/Agency:
R01 AA020822/AA/NIAAA NIH HHS; R01 DK052067/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/KRAS protein, human; 0/Proto-Oncogene Proteins; EC 3.6.5.2/ras Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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