Document Detail

Roles of Intragenic and Intergenic L1s in Mouse and Human.
MedLine Citation:
PMID:  25409429     Owner:  NLM     Status:  Publisher    
Long INterspersed Element-1 (LINE-1 or L1) is a retrotransposable element that has shaped the evolution of mammalian genomes. There is increasing evidence that transcriptionally active L1 could have been co-opted through evolution to play various roles including X-inactivation, homologous recombination and gene regulation. Here, we compare putatively active L1 distributions in the mouse with human. L1 density is higher in the mouse except for the Y-chromosome. L1 density is the highest in X-chromosome, implying an X-inactivation role. L1 is more common outside genes (intergenic) except for the Y-chromosome in both species. The structure of mouse L1 is distinguished from human L1 by the presence of a 200 bp repeat in the 5' UTR of the former. We found that mouse intragenic L1 has significantly higher repeat copy numbers than intergenic L1, suggesting that this is important for control of L1 expression. Furthermore, a significant association between the presence of intragenic L1s and down-regulated genes in early embryogenesis was found in both species. In conclusion, the distribution of L1 in the mouse genome points to biological roles of L1 in mouse similar to human.
Chumpol Ngamphiw; Sissades Tongsima; Apiwat Mutirangura
Related Documents :
25066299 - Systematic comparison of bacterial feeding strains for increased yield of caenorhabditi...
87099 - An analysis of factors for the differential staining of sister chromatids in human chro...
7199799 - Quinacrine mustard and nucleolar organizer region heteromorphisms in twins.
23106559 - Postmating isolation in six species of three genera (hoplobatrachus, euphlyctis and fej...
25186169 - Use of synteny to identify candidate genes underlying qtl controlling stomatal traits i...
11138939 - Cytogenetic analysis of a- and b-chromosomes of prochilodus lineatus (teleostei, prochi...
11543889 - Human y-chromosome variation in the western mediterranean area: implications for the pe...
11144299 - Molecular, serological and genetic studies on two new hla-drb1 alleles--hla-drb1*0704 a...
9341869 - Major histocompatibility complex (mhc) class iii genetics in two amerindian tribes from...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-19
Journal Detail:
Title:  PloS one     Volume:  9     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2014  
Date Detail:
Created Date:  2014-11-19     Completed Date:  -     Revised Date:  2014-11-20    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  -    
Other Details:
Languages:  ENG     Pagination:  e113434     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The Power of Believing: Salient Belief Predictors of Exercise Behavior in Normal Weight, Overweight,...
Next Document:  Design Aspects of a Case-Control Clinical Investigation of the Effect of HIV on Oral and Gastrointes...