Document Detail

Roles of GILZ in protein metabolism of L6 muscle cells exposed to serum from septic rats.
MedLine Citation:
PMID:  25299205     Owner:  NLM     Status:  In-Data-Review    
Sepsis is a complex inflammatory response to infection, associating with dramatic metabolic disorders. Although the mechanisms of immune response during sepsis have been largely clarified, current studies rarely pay attention to the disordered protein metabolism in sepsis. In this study, L6 rat skeletal muscle cells treated with serum from septic rats were used as an in vitro model for sepsis-like condition in skeletal muscle. We found that the expression of glucocorticoid-induced leucine zipper (GILZ) positively correlates with glucocorticoid receptor and negatively correlates with myosin heavy chain expression in L6 muscle cells upon septic serum induction. Moreover, we propose that GILZ may associate with cytokines such as TNF-α, IL-1β as well as IL-10 to cooperatively modulate the glucocorticoid/glucocorticoid receptor-mediated regulation of protein metabolism during sepsis. So the present study provides a new approach and theoretical basis for further studies on the regulation of protein metabolism of skeletal muscle during sepsis.
J Xiong; L Xu; W M Qu; Z L Li; Z H Shang; Y H Li; S H Yang; Z H Yang
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Publication Detail:
Type:  Journal Article     Date:  2014-10-08
Journal Detail:
Title:  Genetics and molecular research : GMR     Volume:  13     ISSN:  1676-5680     ISO Abbreviation:  Genet. Mol. Res.     Publication Date:  2014  
Date Detail:
Created Date:  2014-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101169387     Medline TA:  Genet Mol Res     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  8209-19     Citation Subset:  IM    
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