Document Detail

Role of the zymolyase-sensitive cyst wall of Pneumocystis carinii in the oxidative burst of macrophages.
MedLine Citation:
PMID:  1818188     Owner:  NLM     Status:  MEDLINE    
Alveolar macrophages are thought to participate in clearing Pneumocystis carinii (Pc) from the lungs. We have recently demonstrated that Pc cysts and trophozoites induce an oxidative burst in a cell line of rat alveolar macrophages (NR8383). In order to investigate the mechanism of this response, we examined the effect that disruption of the Pc cyst wall with zymolyase had on the cyst's ability to elicit H2O2 from NR8383 macrophages and correlated these results with the electron microscopic appearance of the cyst wall.
H A Hidalgo; R J Helmke; V F German; J A Mangos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of protozoology     Volume:  38     ISSN:  0022-3921     ISO Abbreviation:  J. Protozool.     Publication Date:    1991 Nov-Dec
Date Detail:
Created Date:  1992-07-14     Completed Date:  1992-07-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985197R     Medline TA:  J Protozool     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  30S-31S     Citation Subset:  IM    
University of Texas Health Science Center, Department of Pediatrics, San Antonio 78284-7815.
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MeSH Terms
Cell Wall / immunology*,  metabolism
Hydrogen Peroxide / metabolism
Hydrolases / metabolism
Macrophages, Alveolar / metabolism*
Pneumocystis / immunology*,  ultrastructure
Pneumonia, Pneumocystis / immunology
Respiratory Burst*
Reg. No./Substance:
37340-57-1/zymolyase; 7722-84-1/Hydrogen Peroxide; EC 3.-/Hydrolases

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