Document Detail


Role of zinc in regulation of arterial blood pressure and in the etiopathogenesis of arterial hypertension.
MedLine Citation:
PMID:  17873391     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Increased gastrointestinal absorption and urinary excretion of zinc has been confirmed in experimental and clinical studies on primary arterial hypertension as a result from changes of intracellular and extracellular zinc content. In arterial hypertension, the levels of zinc in serum, lymphocyte, and bone decrease while increasing in heart, erythrocytes, kidney, liver, suprarenal glands and spleen. These changes result in the loss of zinc homeostasis that leads to various degrees of deficiency, not entirely compensated by nutritional factors or increased absorption in the gastrointestinal tract. Loss of zinc homeostasis can be both cause and effect of high blood pressure. In the present review, the role of zinc metabolism changes and its mechanisms in arterial hypertension are discussed.
Authors:
Sławomir Tubek
Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Biological trace element research     Volume:  117     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  2007  
Date Detail:
Created Date:  2007-09-17     Completed Date:  2007-10-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  39-51     Citation Subset:  IM    
Affiliation:
Faculty of Physical Education and Physiotherapy, Institute of Technology, Opole, and Clinic of Cardiology, Medical Academy, Wrocław, Prószkowska Str. 70, Opole, 45-758, Poland. slawomir.tubek@hipokrates.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteries / metabolism*,  physiology,  physiopathology
Blood Pressure / physiology*
Humans
Hypertension / etiology*,  metabolism*,  physiopathology
Zinc / physiology*
Chemical
Reg. No./Substance:
7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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