Document Detail

Role of xanthine oxidase and its inhibitor in hypoxia: reoxygenation injury.
MedLine Citation:
PMID:  8668378     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This article reviews the biochemistry and function of xanthine dehydrogenase (XDH) and xanthine oxidase (XO) as well as their role in hypoxia-reoxygenation injury. Possible benefits of XO blockade are discussed.
METHODOLOGY: The available literature was reviewed.
RESULTS: It is evident that relatively high activities of XO are restricted to a few organs in man. Because positive effects of XO blockade with allopurinol have been reported even in organs containing relatively low activities of XO, two other possible favorable actions of allopurinol are mentioned. First it may act as an oxygen radical scavenger, and second, it may augment the adenine nucleotides and, hence, adenosine triphosphate concentration in the cell.
CONCLUSIONS: XDH and XO may play an important role in a series of pathophysiologic conditions. Their role in hypoxia-reoxygenation injury has been critically reviewed. However, care should be exercised in starting randomized trials to prevent hypoxia-reoxygenation injury with allopurinol, especially in newborn infants.
SPECULATION: XDH and XO are released from the liver during hypoxic conditions, for instance, and consequently, they may reach a number of organs via the circulation.
O D Saugstad
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pediatrics     Volume:  98     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-08-08     Completed Date:  1996-08-08     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  103-7     Citation Subset:  AIM; IM    
Department of Pediatric Research, National Hospital, Oslo, Norway.
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MeSH Terms
Anoxia / drug therapy,  enzymology*
Enzyme Inhibitors / therapeutic use*
Oxygen / adverse effects*
Xanthine Dehydrogenase / antagonists & inhibitors*,  physiology*
Xanthine Oxidase / antagonists & inhibitors*,  physiology*
Reg. No./Substance:
0/Enzyme Inhibitors; 7782-44-7/Oxygen; EC Dehydrogenase; EC Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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