Document Detail

Role of vitamin A elimination or supplementation diets during postnatal development on the allergic sensitisation in mice.
MedLine Citation:
PMID:  17854093     Owner:  NLM     Status:  MEDLINE    
Vitamin A (VA) and its derivatives, the retinoids, are important factors for the development of the immune system. It has been shown in adult animals that proliferation of lymphocyte populations and antibody secretion are retinoid dependent, while little is known about the effects of retinoids during postnatal development. The aim of this study was to investigate the role of VA on allergic sensitisation during lactation and after weaning using an in vivo system for postnatal allergic sensitisation in mice. Different VA diets (basal/VA elimination/VA (as retinyl palmitate) supplemented) were fed to the dams throughout lactation and directly to the pups after weaning. Allergic sensitisation was induced with a single peritoneal ovalbumin (OVA) injection at day 28 after weaning. The phenotype of lymphocytes was analysed by flow cytometry and functional data were obtained by analysis of (IL-4/IFN-gamma) cytokine production and antibody production (OVA-specific IgG1 and IgE) in the offspring. VA/retinyl palmitate supplementation during lactation and after weaning decreased CD3+, CD4+, CD8+ and B220+ populations in splenic lymphocytes but also significantly enhanced IL-4 production and OVA-specific IgE after sensitisation. In contrast, mice fed VA-elimination diet displayed no significant alteration of lymphocyte numbers and a slightly increased IL-4 production. Our results showed that a single allergen injection during postnatal development induces allergic sensitisation whose degree is modified by the VA content of the maternal diet during lactation and the diet of the pups after weaning, indicating an important role of VA on the severity of the allergic sensitisation.
Ralph Rühl; Andrej Hänel; Ada L Garcia; Anja Dahten; Udo Herz; Florian J Schweigert; Margitta Worm
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  51     ISSN:  1613-4125     ISO Abbreviation:  Mol Nutr Food Res     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-25     Completed Date:  2007-12-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1173-81     Citation Subset:  IM    
Department of Nutritional Physiology and Pathophysiology, Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany.
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MeSH Terms
Allergens / administration & dosage,  immunology
Cytokines / analysis
Dietary Supplements
Flow Cytometry
Hypersensitivity / prevention & control*
Immunoglobulin E / blood
Immunoglobulin G / blood
Lymphocyte Count
Lymphocyte Subsets / immunology
Mice, Inbred BALB C
Ovalbumin / immunology
Spleen / chemistry,  cytology
Vitamin A / administration & dosage*
Reg. No./Substance:
0/Allergens; 0/Cytokines; 0/Immunoglobulin G; 11103-57-4/Vitamin A; 37341-29-0/Immunoglobulin E; 9006-59-1/Ovalbumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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