| Role of vitamin d in insulin secretion and insulin sensitivity for glucose homeostasis. | |
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MedLine Citation:
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PMID: 20011094 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Vitamin D functions are not limited to skeletal health benefits and may extend to preservation of insulin secretion and insulin sensitivity. This review summarizes the literature related to potential vitamin D influences on glucose homeostasis and insulin sensitivity. Cross-sectional data provide some evidence that circulating 25-hydroxyvitamin D (25(OH)D) is inversely associated with insulin resistance, although direct measurements of insulin sensitivity are required for confirmation. Reported associations with insulin secretion, however, are contradictory. Available prospective studies support a protective influence of high 25(OH)D concentrations on type 2 diabetes mellitus risk. There is a general lack of consistency in vitamin D intervention outcomes on insulin secretion and sensitivity, likely due to differences in subject populations, length of interventions, and forms of vitamin D supplementation. Vitamin D receptor gene polymorphisms and vitamin D interactions with the insulin like growth factor system may further influence glucose homeostasis. The ambiguity of optimal vitamin D dosing regimens and optimal therapeutic concentrations of serum 25(OH)D limit available intervention studies. Future studies, including cross-sectional and prospective, should be performed in populations at high risk for both vitamin D deficiency and type 2 diabetes mellitus. Well-designed, placebo-controlled, randomized intervention studies are required to establish a true protective influence of vitamin D on glucose homeostasis. |
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Authors:
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Jessica A Alvarez; Ambika Ashraf |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of endocrinology Volume: 2010 ISSN: 1687-8345 ISO Abbreviation: Int J Endocrinol Publication Date: 2010 |
Date Detail:
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Created Date: 2009-12-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101516376 Medline TA: Int J Endocrinol Country: Egypt |
Other Details:
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Languages: eng Pagination: 351385 Citation Subset: - |
Affiliation:
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Department of Nutrition Sciences, University of Alabama at Birmingham, AL 35233, USA. |
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