| Role of vitamin K antagonists from a hepatologist's point of view. | |
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MedLine Citation:
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PMID: 22539098 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Vitamin K antagonists are often used as oral anticoagulants for primary and secondary prevention of thromboembolic events. Vitamin K antagonists induce an anticoagulant effect by interfering with the vitamin K metabolism in the liver. Well-known complications are bleeding events and skin necrosis. Recent data indicate increasing numbers of cases with hepatic complications due to vitamin K antagonists ranging from mild hepatopathy to acute liver failure with high mortality. Hepatotoxicity is usually developed after a few months of latency, which is associated with unspecific symptoms, jaundice, elevated transaminase levels as well as cholestatic enzymes. Hepatotoxicity due to vitamin K antagonists is seldom; however, it should be considered in cases of elevated liver enzymes. In this case coumarin therapy should be discontinued. Caution is needed when changing to another coumarin derivative because cross-reactivity has been described. |
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Authors:
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G Kneiseler; A Canbay; G Gerken |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-28 |
Journal Detail:
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Title: Herz Volume: - ISSN: 1615-6692 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7801231 Medline TA: Herz Country: - |
Other Details:
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Languages: GER Pagination: - Citation Subset: - |
Affiliation:
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Klinik für Gastroenterologie und Hepatologie, Zentrum für Innere Medizin, Universitätsklinikum Essen, Hufelandstr. 55, 45122, Essen, Deutschland. |
Vernacular Title:
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Rolle der Vitamin-K-Antagonisten aus Sicht des Hepatologen. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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