Document Detail


Role of the ventral surface of medulla in the generation of Mayer waves.
MedLine Citation:
PMID:  2508496     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The regions adjacent to the ventrolateral medullary surface (VMS) play critical roles in the regulation of respiratory and cardiovascular function. Furthermore, these areas seem to be important sites for the integration of afferent inputs from certain sensory organs and the source of excitatory inputs to preganglionic sympathetic and parasympathetic neurons. To determine whether the VMS contributes to the generation of nonrespiratory-related periodic oscillations of arterial blood pressure (Mayer waves), excitatory substances, such as N-methyl-D-aspartate (NMDA), cholinergic agonists, and neuropeptides (substance P, neurokinin A, neurotensin), were applied topically to the intermediate area of VMS in anesthetized cats. In addition, the effects of application of lidocaine and inhibitory substances (benzodiazepines) on Mayer waves were studied. After application of excitatory substances to the VMS, we observed oscillations of arterial blood pressure, recurring with a period of 17.8 +/- 10 (SE) s, which had similar characteristics as the Mayer waves recorded during hypercapnia or hypoxia. In addition, cyclic changes in phrenic nerve activity and tracheal tone occurred with the same periodicity as arterial blood pressure oscillation. Application of lidocaine or benzodiazepines on the intermediate area of the VMS abolished Mayer waves observed during hypercapnia, hypoxia, or application of excitatory substances. These findings show for the first time that the VMS can be considered as one of several synaptic relays involved in the generation of arterial blood pressure oscillation, as well as the cyclic changes in phrenic nerve activity and tracheal smooth muscle tone that occur simultaneously.
Authors:
M A Haxhiu; E van Lunteren; E C Deal; N S Cherniack
Related Documents :
1576856 - Physical exercise in essential hypertension.
25119606 - Association of urinary sodium and potassium excretion with blood pressure.
24056406 - The application of high-pressure treatment in the reduction of phosphate levels in brea...
24488616 - Pharmacological interventions for hypertension in children.
17963366 - Kinetics investigation of oh reaction with isoprene at 240-340 k and 1-3 torr using the...
19904656 - Co-exposure to noise, n,n-dimethylformamide, and toluene on 24-hour ambulatory blood pr...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  257     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-11-17     Completed Date:  1989-11-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R804-9     Citation Subset:  IM    
Affiliation:
Department of Medicine, Case Western Reserve University, Cleveland, Ohio.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Aspartic Acid / pharmacology
Blood Pressure* / drug effects
Carbon Dioxide / pharmacology
Cats
Electrocardiography
Female
Lidocaine / pharmacology
Male
Medulla Oblongata / drug effects,  physiology*
Midazolam / pharmacology
N-Methylaspartate
Neuropeptides / pharmacology
Oxygen / pharmacology
Periodicity
Phrenic Nerve / drug effects,  physiology*
Grant Support
ID/Acronym/Agency:
HL 01600/HL/NHLBI NIH HHS; HL 25830/HL/NHLBI NIH HHS; HL-42315/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Neuropeptides; 124-38-9/Carbon Dioxide; 137-58-6/Lidocaine; 56-84-8/Aspartic Acid; 59467-70-8/Midazolam; 6384-92-5/N-Methylaspartate; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Changes in uterine fluid composition and acid-base status during shell formation in the chicken.
Next Document:  Benzodiazepines acting on ventral surface of medulla cause airway dilation.