Document Detail

Role of ventilation strategy on perfluorochemical evaporation from the lungs.
MedLine Citation:
PMID:  11247936     Owner:  NLM     Status:  MEDLINE    
To study the effect of ventilation strategy on perfluorochemical (PFC) elimination profile (evaporative loss profile; E(L)), 6 ml/kg of perflubron were instilled into anesthetized normal rabbits. The strategy was to maintain minute ventilation (VE, in ml/min) in three groups: VE(L) (low-range VE, 208 +/- 2), VE(M) (midrange VE, 250 +/- 9), and VE(H) (high-range VE, 293 +/- 1) over 4 h. In three other groups, respiratory rate (RR, breaths/min) was controlled at 20, 30, or 50 with a constant VE and adjusted tidal volume. PFC content in the expired gas was measured, and E(L) was calculated. There was a significant VE- and time-dependent effect on E(L.) Initially, percent PFC saturation and loss rate decreased in the VE(H) > VE(M) > VE(L) groups, but by 3 h the lower percent PFC saturation resulted in a loss rate such that VE(H) < VE(M) < VE(L) at 4 h. For the groups at constant VE, there was a significant time effect on E(L) but no RR effect. In conclusion, E(L) profile is dependent on VE with little effect of the RR-tidal volume combination. Thus measurement of E(L) and VE should be considered for the replacement dosing schemes during partial liquid ventilation.
M J Jeng; D Trevisanuto; C M Weis; W W Fox; A B Cullen; M R Wolfson; T H Shaffer
Related Documents :
11520726 - Effect of endotoxin on ventilation and breath variability: role of cyclooxygenase pathway.
2369906 - Changes in breathing pattern at loads near perceptual threshold at different work levels.
1184506 - Effects of expiratory threshold loading during steady-state exercise.
10390396 - Progressive mechanical ventilatory constraints with aging.
15070196 - Mapping of calf muscle oxygenation and haemoglobin content during dynamic plantar flexi...
22659536 - Active-assisted cycling improves tremor and bradykinesia in parkinson's disease.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  90     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-03-15     Completed Date:  2001-05-31     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1365-72     Citation Subset:  IM    
Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, Republic of China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Body Weight / physiology
Fluorocarbons / metabolism*
Hemodynamics / physiology
Liquid Ventilation*
Lung / metabolism,  physiology*
Oxygen / blood
Partial Pressure
Pulmonary Circulation / physiology
Pulmonary Gas Exchange
Respiratory Mechanics / physiology
Tidal Volume / physiology
Reg. No./Substance:
0/Fluorocarbons; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Aged bone displays an increased responsiveness to low-intensity resistance exercise.
Next Document:  MRI study of pharyngeal airway changes during stimulation of the hypoglossal nerve branches in rats.