Document Detail

Role of vasopressor administration in patients with acute neurologic injury.
MedLine Citation:
PMID:  19387871     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Pharmacologic blood pressure elevation is often utilized to prevent or treat ischemia in patients with acute neurologic injury, and routinely requires administration of vasopressor agents. Depending on the indication, vasopressor agents may be administered to treat hypotension or to induce hypertension. METHODS: Although numerous guideline statements exist regarding the management of blood pressure in these patients, most recommendations are based largely on Class III evidence. Further, there are few randomized controlled trials comparing vasopressor agents in these patients and selection is often guided by expert consensus. RESULTS: We discuss the clinical evidence regarding vasopressor administration for blood pressure management in patients with acute neurologic injury. The effect of various vasopressors on cerebral hemodynamics is also discussed. CONCLUSION: Although high-quality clinical data are scarce, the available evidence suggests that norepinephrine should be considered as the vasopressor of choice when blood pressure elevation is indicated in patients with acute neurologic injury.
Katie M Muzevich; Stacy A Voils
Publication Detail:
Type:  Journal Article; Review     Date:  2009-04-22
Journal Detail:
Title:  Neurocritical care     Volume:  11     ISSN:  1541-6933     ISO Abbreviation:  Neurocrit Care     Publication Date:  2009  
Date Detail:
Created Date:  2009-07-07     Completed Date:  2009-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101156086     Medline TA:  Neurocrit Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  112-9     Citation Subset:  IM    
Virginia Commonwealth University Health System, Richmond, VA, USA.
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MeSH Terms
Acute Disease
Brain Diseases / drug therapy*
Brain Injuries / drug therapy*
Intensive Care*
Spinal Cord Injuries / drug therapy*
Vasoconstrictor Agents / therapeutic use*
Reg. No./Substance:
0/Vasoconstrictor Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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