Document Detail

Role of vascular endothelial growth factor in the pathophysiology of nonalcoholic steatohepatitis in two rodent models.
MedLine Citation:
PMID:  23299577     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: Our results demonstrate that there is an increased expression of angiogenic factors in the liver in different mouse models for NASH. We found that VEGFR2 blockage attenuates steatosis and inflammation in a diet-induced mouse model for NASH in a preventive and therapeutic setting. Our findings warrant further investigation of the role of angiogenesis in the pathophysiology in NASH.
Stephanie Coulon; Vanessa Legry; Femke Heindryckx; Christophe Van Steenkiste; Christophe Casteleyn; Kim Olievier; Louis Libbrecht; Peter Carmeliet; Bart Jonckx; Jean-Marie Stassen; Hans Van Vlierberghe; Isabelle Leclercq; Isabelle Colle; Anja Geerts
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-03-14
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  57     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-23     Completed Date:  2013-07-05     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1793-805     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Association for the Study of Liver Diseases.
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MeSH Terms
Angiogenesis Inhibitors / pharmacology
Cells, Cultured
Choline Deficiency / complications
Diabetes Mellitus, Type 2 / physiopathology
Disease Models, Animal*
Disease Progression*
Fatty Liver / etiology,  physiopathology*,  prevention & control
Hepatocytes / drug effects,  pathology,  physiology
Lipid Metabolism / physiology
Liver / drug effects,  pathology,  physiopathology
Methionine / deficiency
Mice, Inbred C57BL
Mice, Inbred Strains
Mice, Mutant Strains
Neovascularization, Pathologic / physiopathology*
Pregnancy Proteins / drug effects,  physiology
Vascular Endothelial Growth Factor A / physiology*
Vascular Endothelial Growth Factor Receptor-2 / drug effects,  physiology
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Pregnancy Proteins; 0/Vascular Endothelial Growth Factor A; 144589-93-5/placenta growth factor; AE28F7PNPL/Methionine; EC Endothelial Growth Factor Receptor-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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