Document Detail

Role of vascular endothelial growth factor as a tumour marker in osteosarcoma: a prospective study.
MedLine Citation:
PMID:  23015149     Owner:  NLM     Status:  MEDLINE    
PURPOSE: A prospective study was undertaken to evaluate the diagnostic and prognostic significance of serum levels of vascular endothelial growth factor (VEGF) in patients with primary localised osteosarcoma.
METHODS: Serum VEGF levels were measured by an enzyme-linked immunosorbent assay (ELISA) in blood samples collected prechemotherapy, postchemotherapy, and postsurgery in 40 patients with histologically proven primary osteosarcoma. Comparison was made between serum VEGF level of healthy controls (n = 10) and prechemotherapy patient sera to evaluate its diagnostic potential. Serum VEGF levels of patients with and without metastasis were compared. Immunohistochemical staining was done to establish the correlation between serum and tissue VEGF expression. The Kaplan-Meier curve was used for survival analysis
RESULTS: No significant relationship was observed between serum VEGF levels and age, gender, tumour size, local recurrence or histopathological subtypes of osteosarcoma. We observed significantly raised mean serum VEGF in patient sera compared with healthy controls (p = 0.001). Significant fall in mean serum VEGF level was observed following chemotherapy (p = 0.001). Patients who developed metastases had significantly higher serum VEGF levels compared with the nonmetastatic group (P = 0.001). Serum VEGF levels correlated well with VEGF expression in tissues.
CONCLUSION: Serum VEGF levels might prove to be of diagnostic, predictive and prognostic value in patients with primary osteosarcoma, although further studies with larger sample size and longer follow-up is needed to support the hypothesis.
Shishir Rastogi; Ramakant Kumar; Sukesh Rao Sankineani; Kanniraj Marimuthu; Laxman Rijal; Shyam Prakash; Divesh Jalan; Shah Alam Khan; Mehar C Sharma
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Publication Detail:
Type:  Journal Article     Date:  2012-09-27
Journal Detail:
Title:  International orthopaedics     Volume:  36     ISSN:  1432-5195     ISO Abbreviation:  Int Orthop     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-24     Completed Date:  2013-04-25     Revised Date:  2013-11-05    
Medline Journal Info:
Nlm Unique ID:  7705431     Medline TA:  Int Orthop     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2315-21     Citation Subset:  IM    
Department of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 29, India.
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MeSH Terms
Bone Neoplasms / metabolism,  mortality,  pathology*,  therapy
Combined Modality Therapy
India / epidemiology
Kaplan-Meier Estimate
Lung Neoplasms / secondary
Neoplasm Recurrence, Local
Neovascularization, Pathologic / metabolism*
Osteosarcoma / metabolism,  mortality,  secondary*,  therapy
Prospective Studies
Survival Rate
Tumor Markers, Biological / blood
Vascular Endothelial Growth Factor A / metabolism*
Young Adult
Reg. No./Substance:
0/Tumor Markers, Biological; 0/Vascular Endothelial Growth Factor A

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