Document Detail

Role of vascular endothelial growth factor in pulmonary endothelial cell injury by exercise challenge in asthmatic patients.
MedLine Citation:
PMID:  16809239     Owner:  NLM     Status:  MEDLINE    
This study was designed to examine the role of vascular endothelial growth factor (VEGF) in pulmonary endothelial cell injury by exercise in asthmatics. Post-exercise circulating thrombomodulin (TM) levels were significantly increased in asthmatics. Moreover, the increase in TM levels with exercise was significantly correlated with VEGF level in induced sputum from asthmatics (r = 0.80, p = 0.0007). After inhaled steroid therapy, post-exercise TM levels were significantly decreased, but the increase in TM levels with exercise was also correlated with VEGF level (r = 0.60, p = 0.01). Thus, pulmonary endothelial cells stimulated by VEGF in asthmatic airways may be sensitive to exercise challenge.
Hiroshi Kanazawa; Yoshihiro Tochino; Yukitoshi Ichimaru; Toyoki Kodama; Shigenori Kyoh; Nobuaki Umeda
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of asthma : official journal of the Association for the Care of Asthma     Volume:  43     ISSN:  0277-0903     ISO Abbreviation:  J Asthma     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-06-30     Completed Date:  2006-07-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8106454     Medline TA:  J Asthma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  267-71     Citation Subset:  IM    
Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Abenoku, Osaka, Japan.
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MeSH Terms
Analysis of Variance
Asthma, Exercise-Induced / diagnosis*,  metabolism*
Biological Markers / metabolism
Bronchial Provocation Tests
Case-Control Studies
Cell Proliferation
Endothelial Cells / cytology
Leukocyte Count
Reference Values
Respiratory Function Tests
Risk Assessment
Sensitivity and Specificity
Severity of Illness Index
Sputum / cytology
Thrombomodulin / metabolism*
Vascular Endothelial Growth Factor A / metabolism*
Reg. No./Substance:
0/Biological Markers; 0/Thrombomodulin; 0/Vascular Endothelial Growth Factor A

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