Document Detail

Role of vascular alpha 2-adrenoceptors as targets for circulating catecholamines in the maintenance of blood pressure in anaesthetised spontaneously hypertensive rats.
MedLine Citation:
PMID:  2410726     Owner:  NLM     Status:  MEDLINE    
We examined the blood pressure-lowering effects of the alpha 2-adrenoceptor antagonist rauwolscine in anaesthetised spontaneously hypertensive rats (SHR). In the absence of prior drug, rauwolscine (1-10 mg kg-1) produced dose-dependent falls in diastolic blood pressure (DBP). In the presence of prazosin (1 mg kg-1) to eliminate alpha 1-adrenoceptor-mediated responses, rauwolscine (0.1-1 mg kg-1) lowered DBP in unoperated and sham-operated animals but not in adrenal demedullated animals. Hence, we were able to demonstrate that alpha 2-adrenoceptors are involved in the control of blood pressure in intact anaesthetised SHR but not following adrenal demedullation, suggesting that circulating catecholamines are responsible for these alpha 2-adrenoceptor-mediated pressor effects.
R Sawyer; P Warnock; J R Docherty
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  7     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:    1985 Jul-Aug
Date Detail:
Created Date:  1985-09-19     Completed Date:  1985-09-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  809-12     Citation Subset:  IM    
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MeSH Terms
Adrenal Medulla / physiology
Blood Pressure* / drug effects
Catecholamines / physiology*
Hydralazine / pharmacology
Hypertension / physiopathology*
Prazosin / pharmacology
Rats, Inbred SHR
Receptors, Adrenergic, alpha / drug effects*
Xylazine / pharmacology
Yohimbine / pharmacology
Reg. No./Substance:
0/Catecholamines; 0/Receptors, Adrenergic, alpha; 146-48-5/Yohimbine; 19216-56-9/Prazosin; 7361-61-7/Xylazine; 86-54-4/Hydralazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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