Document Detail


Role of vagus nerves and gastrin in the gastric phase of acid secretion in male anesthetized rats.
MedLine Citation:
PMID:  9124358     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We used the pylorus ligation model to determine the role of vagus nerves and gastrin in acid secretion induced by mechanical and chemical stimulation of the gastric lumen in anesthetized male rats. Gastric distension induced by intragastric instillation of saline resulted in a 17-fold increase in acid secretion over the basal level without an alteration in serum gastrin levels. Distension-stimulated acid secretion was inhibited by bilateral subdiaphragmatic vagotomy but not by CI-988, a gastrin receptor antagonist. Intragastric peptone produced a 71-fold increase in acid secretion over the basal level that was accompanied by a significant increase in serum gastrin levels. Whereas vagotomy almost abolished peptone-stimulated acid secretion, CI-988 inhibited peptone-stimulated acid secretion by only 50%. We conclude that the vagus nerves mediate acid secretion by mechanical and chemical stimulation and that gastrin mediates acid secretion partly by chemical stimulation but not by mechanical stimulation in anesthetized male rats.
Authors:
T Noto; M Nagasaki; T Endo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  272     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-04-24     Completed Date:  1997-04-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G335-9     Citation Subset:  IM    
Affiliation:
Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd., Toda, Saitama, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Deoxyglucose / pharmacology
Gastric Acid / secretion*
Gastric Mucosa / drug effects,  secretion*
Gastrins / physiology*
Hormone Antagonists / pharmacology
Indoles / pharmacology
Male
Meglumine / analogs & derivatives,  pharmacology
Peptones / antagonists & inhibitors,  pharmacology
Physical Stimulation
Rats
Rats, Wistar
Stomach / physiology
Vagotomy
Vagus Nerve / physiology*
Chemical
Reg. No./Substance:
0/Gastrins; 0/Hormone Antagonists; 0/Indoles; 0/Peptones; 130404-91-0/PD 134308; 154-17-6/Deoxyglucose; 6284-40-8/Meglumine

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