| Role of utero-ovarian vascular impedance: predictor of ongoing pregnancy in an IVF-embryo transfer programme. | |
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MedLine Citation:
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PMID: 15353081 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to evaluate the role of uterine, endometrial and follicular blood flow in prediction of ongoing pregnancy after assisted conception. A prospective observational study was conducted on 53 women undergoing IVF treatment. Transvaginal colour and pulsed Doppler measurements were performed on the day that pituitary suppression was confirmed, on day 10 of ovarian stimulation and on the day prior to human chorionic gonadotrophin injection. On the last day of ovarian stimulation, blood flow in the ascending uterine artery of the women who would conceive was characterized by significantly lower pulsatility index values. Sub-endometrial vascular impedance was comparable in the pregnant and non-pregnant groups. There were no differences in the perifollicular vascularity between pregnant and non-pregnant women. The chance of achieving pregnancy predicted by uterine artery Doppler and perifollicular blood flow in women whose PI values were higher than 3.26 and 1.08 was very low, with a sensitivity of 1.00 and specificity of 0.59 and 0.82 respectively. The data provide evidence for an association between utero-ovarian perfusion and reproductive outcome following IVF treatment. Uterine and ovarian vascular impedance values identify those women whose pregnancy chances are significantly limited. Measures to decrease vascular impedance in such women might enhance pregnancy rates by improving embryo quality and uterine receptivity for implantation. |
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Authors:
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Ozkan Ozturk; Siladitya Bhattacharya; Ertan Saridogan; Eric Jauniaux; Allan Templeton |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Reproductive biomedicine online Volume: 9 ISSN: 1472-6483 ISO Abbreviation: Reprod. Biomed. Online Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-09-08 Completed Date: 2005-03-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101122473 Medline TA: Reprod Biomed Online Country: England |
Other Details:
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Languages: eng Pagination: 299-305 Citation Subset: IM |
Affiliation:
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Academic Department of Obstetrics and Gynaecology, University College London Hospitals, London, UK. ozkanozturk@tesco.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Embryo Transfer* Endometrium / blood supply* Estradiol / blood Female Fertilization in Vitro* Follicle Stimulating Hormone Gonadotropin-Releasing Hormone Gonadotropins Humans Immunoradiometric Assay Ovary / blood supply* Pregnancy Pregnancy Outcome Prospective Studies Regional Blood Flow Sensitivity and Specificity Ultrasonography, Doppler, Pulsed Uterus / blood supply* |
| Chemical | |
Reg. No./Substance:
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0/Gonadotropins; 33515-09-2/Gonadotropin-Releasing Hormone; 50-28-2/Estradiol; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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