Document Detail

Role of utero-ovarian vascular impedance: predictor of ongoing pregnancy in an IVF-embryo transfer programme.
MedLine Citation:
PMID:  15353081     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to evaluate the role of uterine, endometrial and follicular blood flow in prediction of ongoing pregnancy after assisted conception. A prospective observational study was conducted on 53 women undergoing IVF treatment. Transvaginal colour and pulsed Doppler measurements were performed on the day that pituitary suppression was confirmed, on day 10 of ovarian stimulation and on the day prior to human chorionic gonadotrophin injection. On the last day of ovarian stimulation, blood flow in the ascending uterine artery of the women who would conceive was characterized by significantly lower pulsatility index values. Sub-endometrial vascular impedance was comparable in the pregnant and non-pregnant groups. There were no differences in the perifollicular vascularity between pregnant and non-pregnant women. The chance of achieving pregnancy predicted by uterine artery Doppler and perifollicular blood flow in women whose PI values were higher than 3.26 and 1.08 was very low, with a sensitivity of 1.00 and specificity of 0.59 and 0.82 respectively. The data provide evidence for an association between utero-ovarian perfusion and reproductive outcome following IVF treatment. Uterine and ovarian vascular impedance values identify those women whose pregnancy chances are significantly limited. Measures to decrease vascular impedance in such women might enhance pregnancy rates by improving embryo quality and uterine receptivity for implantation.
Ozkan Ozturk; Siladitya Bhattacharya; Ertan Saridogan; Eric Jauniaux; Allan Templeton
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  9     ISSN:  1472-6483     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-09-08     Completed Date:  2005-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  299-305     Citation Subset:  IM    
Academic Department of Obstetrics and Gynaecology, University College London Hospitals, London, UK.
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MeSH Terms
Embryo Transfer*
Endometrium / blood supply*
Estradiol / blood
Fertilization in Vitro*
Follicle Stimulating Hormone
Gonadotropin-Releasing Hormone
Immunoradiometric Assay
Ovary / blood supply*
Pregnancy Outcome
Prospective Studies
Regional Blood Flow
Sensitivity and Specificity
Ultrasonography, Doppler, Pulsed
Uterus / blood supply*
Reg. No./Substance:
0/Gonadotropins; 33515-09-2/Gonadotropin-Releasing Hormone; 50-28-2/Estradiol; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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