Document Detail


Role of uric acid in different types of calcium oxalate renal calculi.
MedLine Citation:
PMID:  16643619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: The presence of uric acid in the beginning zone of different types of 'pure' calcium oxalate renal calculi was evaluated with the aim of establishing the degree of participation of uric acid crystals in the formation of such calculi. METHODS: The core or fragment of different types of 'pure' calcium oxalate renal calculi was detached, pulverized and uric acid extracted. Uric acid was determined using a high-performance liquid chromatography/mass spectrometry method. RESULTS: In calcium oxalate monohydrate (COM) papillary calculi with a core constituted by COM crystals and organic matter, 0.030+/-0.007% uric acid was found in the core. In COM papillary calculi with a core constituted by hydroxyapatite, 0.031+/-0.008% uric acid was found in the core. In COM unattached calculi (formed in renal cavities) with the core mainly formed by COM crystals and organic matter, 0.24+/-0.09% uric acid was found in the core. In COM unattached calculi with the core formed by uric acid identifiable by scanning electron microscopy (SEM) coupled to X-ray microanalysis, 20.8+/-7.8% uric acid was found in the core. In calcium oxalate dihydrate (COD) unattached calculi containing little amounts of organic matter, 0.012+/-0.004% uric acid was found. In COD unattached calculi containing little amounts of organic matter and hydroxyapatite, 0.0030+/-0.0004% of uric acid was found. CONCLUSIONS: From these results it can be deduced that uric acid can play an important role as inducer (heterogeneous nucleant) of COM unattached calculi with the core formed by uric acid identifiable by SEM coupled to X-ray microanalysis (these calculi constitute the 1.2% of all calculi) and in COM unattached calculi with the core mainly formed by COM crystals and organic matter (these calculi constitute the 10.8% of all calculi).
Authors:
Félix Grases; Pilar Sanchis; Joan Perelló; Antonia Costa-Bauzá
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of urology : official journal of the Japanese Urological Association     Volume:  13     ISSN:  0919-8172     ISO Abbreviation:  Int. J. Urol.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-04-28     Completed Date:  2006-10-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9440237     Medline TA:  Int J Urol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  252-6     Citation Subset:  IM    
Affiliation:
Laboratory of Renal Lithiasis Research, Institute of Health Sciences Research (IUNICS), University of Balearic Islands, Mallorca, Spain. fgrases@uib.es
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MeSH Terms
Descriptor/Qualifier:
Calcium Oxalate / analysis*
Chromatography, High Pressure Liquid
Humans
Hydrogen-Ion Concentration
Kidney Calculi / chemistry*,  pathology,  urine
Microscopy, Electron, Scanning
Uric Acid / urine*
Chemical
Reg. No./Substance:
25454-23-3/Calcium Oxalate; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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