| Role of unstirred water layer in the exsorption of quinidine. | |
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MedLine Citation:
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PMID: 1979626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intestinal ++exsorption of salicylic acid, thiopentone, theophylline, and quinidine was measured during perfusion of the intestinal lumen with Tyrode solution. The effect of pectin or bovine serum albumin added to the perfusate on intestinal clearance (CLi) was investigated. Increasing pectin concentration from 0.0 to 0.5, 1.0 and 1.5% gave CLi values for quinidine of 499 +/- 18, 363 +/- 35, 237 +/- 56, and 300 +/- 28 mL h-1 kg-1, respectively. One per cent of pectin in the perfusate also decreased the CLi of thiopentone, but had no effect on the CLi of salicylic acid or theophylline. Pectin may have increased the thickness of the unstirred water layer on the mucous membrane and the resistance of drug exsorption for some drugs. When bovine serum albumin was added, drug binding in the perfusate increased, and the CLi of salicylic acid, thiopentone, and theophylline increased; the CLi of quinidine was unaltered. Co-administration of theophylline with quinidine decreased the CLi of quinidine without affecting quinidine binding in serum or in the perfusate. The CLi theophylline was not affected by quinidine. These observations are consistent with the hypothesis that the exsorption of quinidine is rate-limited by diffusion through the unstirred water layer on the mucous membrane. The CLi of quinidine is affected by the microclimate-pH in the unstirred water layer. An alternative possibility is that quinidine exsorption is mediated by a carrier-transport pathway. |
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Authors:
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J D Huang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pharmacy and pharmacology Volume: 42 ISSN: 0022-3573 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 1990 Jun |
Date Detail:
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Created Date: 1991-01-25 Completed Date: 1991-01-25 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 435-7 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, National Cheng Kung University, Medical College, Tainan, Taiwan Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chemistry, Physical Diffusion Intestinal Absorption / drug effects Male Pectins / pharmacology Perfusion Physicochemical Phenomena Quinidine / chemistry, pharmacokinetics* Rats Rats, Inbred Strains Salicylic Acid Salicylic Acids / pharmacokinetics Serum Albumin, Bovine / pharmacology Theophylline / pharmacokinetics Thiopental / pharmacokinetics |
| Chemical | |
Reg. No./Substance:
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0/Pectins; 0/Salicylic Acids; 0/Serum Albumin, Bovine; 56-54-2/Quinidine; 58-55-9/Theophylline; 69-72-7/Salicylic Acid; 76-75-5/Thiopental |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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