Document Detail


Role of tubular cells in progressive renal disease.
MedLine Citation:
PMID:  10352408     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is generally accepted that the progressive loss of kidney function results from a pathogenic process that is independent of the original etiology, functioning as a final common pathway. Part of this response is characterized by triggering of interstitial infiltration and induction of tubular damage. As a consequence, tubular epithelial cells (TEC) can become activated and begin to express several inflammatory mediators. In the present review, we will summarize the potential role of TEC in progressive renal disease. Much emphasis will be put on studies using in vitro cultured TEC. These studies have provided more insight into the different signals involved in the regulation of the production of inflammatory mediators like complement, cytokines and chemokines, as well as progression factors like growth factors and matrix component by TEC.
Authors:
C van Kooten; A M Langers; J A Bruijn; M R Daha
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Kidney & blood pressure research     Volume:  22     ISSN:  1420-4096     ISO Abbreviation:  Kidney Blood Press. Res.     Publication Date:  1999  
Date Detail:
Created Date:  1999-07-08     Completed Date:  1999-07-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9610505     Medline TA:  Kidney Blood Press Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  53-61     Citation Subset:  IM    
Affiliation:
Department of Nephrology, Leiden University Medical Center, Leiden, the Netherlands. Kooten@Rullf2.Medfac.LeidenUniv.nl
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, CD40 / physiology
Disease Progression
Epithelial Cells / physiology
Humans
Kidney Diseases / pathology,  physiopathology*
Kidney Tubules / pathology,  physiopathology*
Chemical
Reg. No./Substance:
0/Antigens, CD40

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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