| Role of tubular cells in progressive renal disease. | |
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MedLine Citation:
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PMID: 10352408 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is generally accepted that the progressive loss of kidney function results from a pathogenic process that is independent of the original etiology, functioning as a final common pathway. Part of this response is characterized by triggering of interstitial infiltration and induction of tubular damage. As a consequence, tubular epithelial cells (TEC) can become activated and begin to express several inflammatory mediators. In the present review, we will summarize the potential role of TEC in progressive renal disease. Much emphasis will be put on studies using in vitro cultured TEC. These studies have provided more insight into the different signals involved in the regulation of the production of inflammatory mediators like complement, cytokines and chemokines, as well as progression factors like growth factors and matrix component by TEC. |
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Authors:
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C van Kooten; A M Langers; J A Bruijn; M R Daha |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Kidney & blood pressure research Volume: 22 ISSN: 1420-4096 ISO Abbreviation: Kidney Blood Press. Res. Publication Date: 1999 |
Date Detail:
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Created Date: 1999-07-08 Completed Date: 1999-07-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9610505 Medline TA: Kidney Blood Press Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 53-61 Citation Subset: IM |
Affiliation:
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Department of Nephrology, Leiden University Medical Center, Leiden, the Netherlands. Kooten@Rullf2.Medfac.LeidenUniv.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD40 / physiology Disease Progression Epithelial Cells / physiology Humans Kidney Diseases / pathology, physiopathology* Kidney Tubules / pathology, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD40 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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