| Role of tryptophan in carcinogenesis. | |
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MedLine Citation:
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PMID: 3591519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper reviews some of the earlier experimental studies concerning the role that tryptophan plays in enhancing tumorigenesis induced by selected chemical carcinogens. For many years, tryptophan has been implicated in carcinogenesis of the bladder. The evidence regarding tryptophan's effect on hepatic tumorigenesis is conflicting; an enhancing effect has been reported by some investigators, but a reduction in tumorigenesis has been reported by other workers. Some of the unique effects that tryptophan exerts upon the liver are reviewed. Also, experimental studies from our laboratory are reported in which we observed a potentiating effect of increased dietary tryptophan on the induction of gamma-glutamyltranspeptidase-positive foci in liver when rats were fed a choline-supplemented diet but no potentiation was found when rats were fed a choline-deficient diet for 10 weeks. The results suggest that increased dietary tryptophan has a promoting effect on liver carcinogenesis as measured by the induction of gamma-glutamyltranspeptidase-positive foci in the livers of rats exposed to diethylnitrosamine. The possible significance of these findings is reviewed. |
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Authors:
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H Sidransky |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 206 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 1986 |
Date Detail:
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Created Date: 1987-06-26 Completed Date: 1987-06-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 187-207 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinogens* Glutathione / metabolism Liver / drug effects, metabolism Liver Neoplasms / chemically induced, pathology* Ornithine Decarboxylase / metabolism Rats Tryptophan / toxicity* Urinary Bladder Neoplasms / chemically induced, pathology* |
| Grant Support | |
ID/Acronym/Agency:
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AM-27339/AM/NIADDK NIH HHS; CA-26557/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 70-18-8/Glutathione; 73-22-3/Tryptophan; EC 4.1.1.17/Ornithine Decarboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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