| Role of transperineal six-core prostate biopsy in patients with prostate-specific antigen level greater than 10 ng/mL and abnormal digital rectal examination findings. | |
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MedLine Citation:
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PMID: 16527579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To define whether six-core biopsies still have a role in patients presenting with prostate-specific antigen (PSA) levels greater than 10 ng/mL and abnormal digital rectal examination (DRE) findings. Recent studies have suggested that the six-core biopsy is inadequate for the diagnosis of prostate cancer; however, it remains controversial whether an increased number of cores is justified in all patients. METHODS: From June 2002 to February 2005, 122 (18.8%) of 650 patients underwent prostate biopsy because of a PSA level greater than 10 ng/mL and abnormal DRE findings. All patients underwent transperineal ultrasound-guided prostate biopsy in a standardized fashion: a six-core biopsy was performed first, followed by six additional cores during the same session, four in the peripheral and two in the transition zone. RESULTS: The detection rate in patients with a PSA level greater than 10 ng/mL and abnormal DRE findings was 72.1% (88 of 122) and 75.4% (92 of 122) using the 6-core and 12-core biopsy, respectively. One case of tumor was missed by the six-core biopsy among patients with a PSA level greater than 15 ng/mL and abnormal DRE findings. No cases of tumor were missed by six-core biopsy in the group with a PSA level greater than 20 ng/mL and abnormal DRE findings. CONCLUSIONS: Six-core biopsy provided a similar cancer detection rate compared with 12-core biopsy in patients with PSA levels greater than 10 ng/mL and abnormal DRE findings. An initial approach with 6-core biopsy is reasonable in patients with a PSA level greater than 10 ng/mL and abnormal DRE findings and is advocated in those with PSA greater than 20 ng/mL and abnormal DRE findings. |
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Authors:
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Lorenzo G Luciani; Gioacchino De Giorgi; Claudio Valotto; Martina Zanin; Sergio Bierti; Filiberto Zattoni |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Urology Volume: 67 ISSN: 1527-9995 ISO Abbreviation: Urology Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-10 Completed Date: 2006-04-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0366151 Medline TA: Urology Country: United States |
Other Details:
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Languages: eng Pagination: 555-8 Citation Subset: IM |
Affiliation:
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Department of Urology, S.M. Misericordia Hospital/University of Udine, Udine, Italy. lorenzo_luciani@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Biopsy / methods, statistics & numerical data* Digital Rectal Examination* Humans Male Middle Aged Perineum Prostate / pathology* Prostate-Specific Antigen / blood* Prostatic Neoplasms / diagnosis* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.77/Prostate-Specific Antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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