Document Detail


Role of transcription factors in cell replacement therapies for neurodegenerative conditions.
MedLine Citation:
PMID:  20455654     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Parkinson's disease is the second most common neurological condition, behind dementia, for which there is currently no cure. A promising curative treatment approach is cell replacement therapy, which involves the introduction of new dopaminergic cells into a degenerative Parkinson's disease brain. The future progression of this field into a clinically viable treatment option is reliant on generating replacement dopaminergic cells. Furthermore, as the ability of transplanted dopaminergic neurons to form connections with host tissue is dependent on where the cells are derived from, the replacement dopaminergic cells will need to be phenotypically similar to substantia nigra dopaminergic neurons. This article focuses on how developmental transcription factors have been utilized to assist the progression of stem cell therapies for Parkinson's disease. Key transcription factor-mediated stages of substantia nigra dopaminergic neuronal development is described in the belief that a comprehensive understanding of this specific dopaminergic differentiation pathway is necessary for the progression of successful cell therapies for Parkinson's disease.
Authors:
Meghan Thomas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Regenerative medicine     Volume:  5     ISSN:  1746-076X     ISO Abbreviation:  Regen Med     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-11     Completed Date:  2010-10-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101278116     Medline TA:  Regen Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  441-50     Citation Subset:  IM    
Affiliation:
Parkinson's Center (ParkC), Vario Health Institute, Edith Cowan University, Perth, Australia. m.thomas@ecu.edu.au
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MeSH Terms
Descriptor/Qualifier:
Animals
Blastocyst / metabolism
Cell Differentiation
Dopamine / metabolism
Humans
Mice
Mitosis
Neurodegenerative Diseases / therapy*
Neurons / metabolism
Parkinson Disease / therapy*
Regenerative Medicine / methods*
Stem Cell Transplantation / methods
Substantia Nigra / metabolism
Tissue Therapy / methods*
Transcription Factors / metabolism*
Chemical
Reg. No./Substance:
0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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