| Role of toxic oxygen products from phagocytic cells in tissue injury. | |
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MedLine Citation:
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PMID: 6308973 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The generation of toxic oxygen products from activated phagocytic cells represents an important pathogenic mechanism in tissue damage associated with inflammatory reactions that are characterized by the involvement of neutrophils or other phagocytic cells. The production of these toxic products from activated phagocytic cells is related to receptor activation on the surface of the cells. Most emphasis has been placed on studies in the lung where the production of these toxic metabolites by phagocytic cells, either in the vasculature or in the airway compartment of the lungs, has been demonstrated to result in endothelial cell injury or damage and destruction of alveolar lining cells. In some cases these reactions are progressive, resulting in parenchymal collapse and fibrosis. Naturally occurring protective factors have been demonstrated both within cells and in the plasma and interstitial fluid compartments. Although there is increasing evidence that in the shock syndrome complement activation products and toxic oxygen metabolites from activated leukocytes play important roles, the most direct evidence for related mechanisms comes in detailed studies of immune complex induced injury where a role for both O-2 and H2O2 has been clearly demonstrated. These facts indicate that toxic oxygen metabolites from activated phagocytic cells play important roles in a variety of pathological situations, and have provided new insights into intervention therapy. |
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Authors:
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P A Ward |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Advances in shock research Volume: 10 ISSN: 0195-878X ISO Abbreviation: Adv Shock Res Publication Date: 1983 |
Date Detail:
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Created Date: 1983-09-09 Completed Date: 1983-09-09 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7908298 Medline TA: Adv Shock Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 27-34 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigen-Antibody Complex / physiology Arthus Reaction / immunology, pathology Complement C5 / physiology Complement C5a Free Radicals Hydrogen Peroxide / metabolism Inflammation / immunology*, pathology Neutrophils / immunology* Oxygen / metabolism* Phagocytosis* Rats Superoxide Dismutase / physiology Superoxides / biosynthesis Tetradecanoylphorbol Acetate / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antigen-Antibody Complex; 0/Complement C5; 0/Free Radicals; 11062-77-4/Superoxides; 16561-29-8/Tetradecanoylphorbol Acetate; 7722-84-1/Hydrogen Peroxide; 7782-44-7/Oxygen; 80295-54-1/Complement C5a; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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