| Role of topical chemotherapy for primary acquired melanosis and malignant melanoma of the conjunctiva and cornea: review of the evidence and recommendations for treatment. | |
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MedLine Citation:
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PMID: 16970772 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Surgical excision with cryotherapy is a well-established treatment option for malignant melanoma or primary acquired melanosis (PAM) with atypia of the conjunctiva and cornea. Topical chemotherapeutic agents such as mitomycin C (MMC) however, are increasingly finding use in clinical practice. A search was performed of Medline and Pubmed databases for English language articles from 1980 to the present in this field. Relevant studies were reviewed with regards to treatment regimen, rates of recurrence and metastasis, side effect profile and length of follow up. A total of 22 and 16 unique cases of biopsy proven PAM with atypia and malignant melanoma, respectively, treated with topical MMC were identified. Topical MMC was well tolerated and shows considerable promise, particularly in the treatment of diffuse PAM with atypia. However, long-term data are lacking and further studies are required. |
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Authors:
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Rajeev Chalasani; Michael Giblin; R Max Conway |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical & experimental ophthalmology Volume: 34 ISSN: 1442-6404 ISO Abbreviation: Clin. Experiment. Ophthalmol. Publication Date: 2006 Sep-Oct |
Date Detail:
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Created Date: 2006-09-14 Completed Date: 2006-11-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100896531 Medline TA: Clin Experiment Ophthalmol Country: Australia |
Other Details:
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Languages: eng Pagination: 708-14 Citation Subset: IM |
Affiliation:
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Ocular Oncology Unit, Save Sight Institute, Sydney Eye Hospital, Sydney, New South Wales, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Antibiotics, Antineoplastic / therapeutic use* Conjunctival Neoplasms / drug therapy* Corneal Diseases / drug therapy* Databases, Factual Eye Neoplasms / drug therapy* Humans Melanoma / drug therapy* Melanosis / drug therapy* Mitomycin / therapeutic use* Practice Guidelines as Topic |
| Chemical | |
Reg. No./Substance:
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0/Antibiotics, Antineoplastic; 50-07-7/Mitomycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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