Document Detail

Role of the tissue renin-angiotensin system in vascular remodeling and smooth muscle cell growth.
MedLine Citation:
PMID:  7842273     Owner:  NLM     Status:  MEDLINE    
In recent years numerous data have given evidence that the tissue renin-angiotensin system may play an equal or perhaps an even more important role than the circulating renin-angiotensin system in numerous physiologic processes. This was first suggested by the observation that the blood pressure lowering effect of angiotension-converting enzyme (ACE) inhibitors correlates better with tissue ACE activity than with plasma ACE activity. In response to hypertension and arterial injury, vascular smooth muscle cells undergo three responses: hypertrophy, hyperplasia, and remodeling. The end result is a decrease in lumen diameter and an increase in peripheral vascular resistance. Blockade of angiotensin II formation inhibits these smooth muscle responses in a number of animal models. This review discusses the evidence supporting the existence of local tissue renin-angiotensin system in the vasculature and its physiologic effects. Inhibition of the vascular renin-angiotensin system may have important implications in the treatment of patients with hypertension, atherosclerosis, and restenosis following balloon coronary angioplasty.
A J Naftilan
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in nephrology and hypertension     Volume:  3     ISSN:  1062-4821     ISO Abbreviation:  Curr. Opin. Nephrol. Hypertens.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1995-03-08     Completed Date:  1995-03-08     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9303753     Medline TA:  Curr Opin Nephrol Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  218-27     Citation Subset:  IM    
Vanderbilt University School of Medicine, Division of Cardiology, Nashville, TN 37232-2170.
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MeSH Terms
Cell Division
Growth Substances / physiology
Muscle, Smooth, Vascular / cytology,  enzymology,  metabolism*
Renin-Angiotensin System / physiology*
Reg. No./Substance:
0/Growth Substances

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