| Role of tissue factor in pregnancy complications: crosstalk between coagulation and inflammation. | |
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MedLine Citation:
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PMID: 21262438 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Bad pregnancy outcomes have been associated with increased activation of the coagulation cascade and inflammation, in particular the activation of the complement cascade. Recent studies have suggested that inflammatory processes modulate thrombogenic pathways and vice versa. We studied the cross-talk between the coagulation and the complement cascade in the pathogenesis of recurrent miscarriages and preeclampsia in mice. We identified tissue factor (TF) as a crucial mediator of fetal and placental damage in mouse models of recurrent miscarriages and preeclampsia. Increased TF expression increases the release of reactive oxygen species and antiangiogenic molecules from inflammatory cells inducing trophoblast damage and bad pregnancy outcomes. We also demonstrated that pravastatin, by downregulating TF expression, prevents miscarriages and the onset of preeclampsia in mice. |
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Authors:
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Guillermina Girardi |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Thrombosis research Volume: 127S3 ISSN: 1879-2472 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-1-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0326377 Medline TA: Thromb Res Country: - |
Other Details:
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Languages: ENG Pagination: S43-S46 Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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York College - CUNY - New York, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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