Document Detail

Role of thyroidectomy in advanced laryngeal and pharyngolaryngeal carcinoma.
MedLine Citation:
PMID:  20493357     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Total thyroidectomy (TThy) or hemithyroidectomy (HThy) in conjunction with a total laryngectomy (TL) or pharyngolaryngectomy (PL) for laryngeal carcinoma often results in hypothyroidism requiring life-long thyroid hormone replacement. The aims were to determine the incidence of thyroid gland (TG) invasion in patients undergoing TL or TPL with TThy or HThy for laryngeal or hypopharyngeal carcinoma and to assess predicative factors. STUDY DESIGN: Case series with chart review. SETTING: Guy's Hospital, London, UK. SUBJECTS AND METHODS: Thirty-five patients from 2004 to 2008 were reviewed. Specimens were examined to determine the incidence of TG invasion and predicative factors. Preoperative imaging was reviewed to assess the radiological evidence of TG invasion. RESULTS: TL and TThy were performed in 19 patients, TL and HThy in three patients, and PL and TThy in 13 patients. Surgery was performed for primary and recurrent carcinoma in 28 and eight patients, respectively. Histological evidence of invasion of the TG was found in three patients (8.5%). No significant relationship was found between TG invasion and patient's sex, subsite of primary carcinoma, stage of primary disease at surgery, degree of differentiation, or the presence of subglottic extension. In addition, no significant relationship was found between the presence of TG invasion and recurrent disease. Definite evidence of radiological invasion of the TG was seen in only one patient. CONCLUSIONS: Invasion of the TG in patients undergoing TL or TPL is a rare event and limits the need for TThy in most cases.
Michael S Elliott; Edward W Odell; James R Tysome; Steve E J Connor; Ata Siddiqui; Jean-Pierre Jeannon; Ricard Simo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery     Volume:  142     ISSN:  1097-6817     ISO Abbreviation:  Otolaryngol Head Neck Surg     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-24     Completed Date:  2010-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508176     Medline TA:  Otolaryngol Head Neck Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  851-5     Citation Subset:  IM    
Copyright Information:
Copyright 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved.
Department of Otolaryngology, Guy's & St. Thomas' NHS Foundation Trust, London, UK.
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MeSH Terms
Laryngeal Neoplasms / pathology*,  radiography,  surgery
Middle Aged
Neoplasm Invasiveness
Neoplasm Recurrence, Local / pathology*,  surgery
Pharyngeal Neoplasms / pathology*,  surgery
Retrospective Studies
Thyroid Gland / pathology*
Tomography, X-Ray Computed

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