| Role of thrombolytic agents in cardiac arrest. | |
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MedLine Citation:
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PMID: 16988298 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The prognosis of patients having a cardiac arrest is generally poor, with a few exceptions. Interventions that aim to improve outcome in cardiac arrest have proved to be disappointing. In particular, no drug has been reliably proved to increase survival to discharge after cardiac arrest. Given that coronary thrombosis in situ and pulmonary thromboembolism are implicated in a large proportion of patients with cardiac arrest, the use of thrombolytic agents has been suggested. Case reports and animal studies have shown favourable results, and have proposed plausible mechanisms to explain them. This is a review of the current literature focusing on the use of thrombolysis during cardiac arrest. A comprehensive literature search was carried out on Medline from 1966 to January 2006, Embase from 1988 to January 2006 and the Cochrane Library, using the Ovid interface. Six articles were selected for review. Although some results are encouraging, all the studies currently available are limited by size and flaws in design. |
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Authors:
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D K Pedley; W G Morrison |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Emergency medicine journal : EMJ Volume: 23 ISSN: 1472-0213 ISO Abbreviation: Emerg Med J Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-09-21 Completed Date: 2007-03-22 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 100963089 Medline TA: Emerg Med J Country: England |
Other Details:
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Languages: eng Pagination: 747-52 Citation Subset: IM |
Affiliation:
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Department of Academic Emergency Medicine, James Cook University Hospital, Middlesbrough TS4 3BW, UK. dpedley@doctors.org.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cerebrovascular Circulation / drug effects Fibrinolytic Agents / adverse effects, therapeutic use* Heart Arrest / drug therapy*, physiopathology Humans Research Design Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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