Document Detail

Role of a third generation calcium antagonist in the management of hypertension.
MedLine Citation:
PMID:  10529076     Owner:  NLM     Status:  MEDLINE    
Calcium antagonists are uniquely suitable for managing hypertension by virtue of their efficacy, metabolic neutrality and their ability to countervail counterregulatory adaptive changes, thereby enhancing blood pressure lowering. Recent evidence has accrued underscoring the concept that calcium antagonists are heterogeneous and consist of chemically dissimilar agents. The difference in formulations and pharmacokinetics affect clinical events including the effect on blood pressure, heart rate and the degree with which sympathetic activity is activated. Lacidipine is a new calcium antagonist that is the prototype of the lipophilic dihydropyridines. Of great importance, lacidipine has a slow onset of vasodilator/antihypertensive effect and does not promote an excessive sympathetic drive. These attributes commend its selection as an antihypertensive agent.
M Epstein
Related Documents :
8842136 - Resistant hypertension: an overview.
15558916 - A systematic approach to managing hypertension and the metabolic syndrome in primary care.
1999906 - Antihypertensive therapy. to stop or not to stop?
18728576 - Prospective randomized comparison of safety and efficacy of nicardipine and nitroprussi...
1401726 - Three-dimensional analysis of systolic blood pressure and r-r interval: proposal of sel...
17126656 - Effects of levosimendan on right ventricular function in patients with advanced heart f...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Drugs     Volume:  57 Suppl 1     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  1999  
Date Detail:
Created Date:  1999-11-17     Completed Date:  1999-11-17     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  1-10     Citation Subset:  IM    
Department of Medicine, University of Miami School of Medicine, Florida, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antihypertensive Agents / pharmacokinetics,  pharmacology*,  therapeutic use
Calcium Channel Blockers / pharmacokinetics,  pharmacology*,  therapeutic use
Dihydropyridines / pharmacokinetics,  pharmacology,  therapeutic use
Hypertension / drug therapy*
Reg. No./Substance:
0/Antihypertensive Agents; 0/Calcium Channel Blockers; 0/Dihydropyridines; 103890-78-4/lacidipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Tryptophan depletion: a predictor of future depressive episodes in seasonal affective disorder?
Next Document:  Impact of calcium antagonists on the cardiovascular system: experience with lacidipine.