| Role of a third generation calcium antagonist in the management of hypertension. | |
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MedLine Citation:
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PMID: 10529076 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Calcium antagonists are uniquely suitable for managing hypertension by virtue of their efficacy, metabolic neutrality and their ability to countervail counterregulatory adaptive changes, thereby enhancing blood pressure lowering. Recent evidence has accrued underscoring the concept that calcium antagonists are heterogeneous and consist of chemically dissimilar agents. The difference in formulations and pharmacokinetics affect clinical events including the effect on blood pressure, heart rate and the degree with which sympathetic activity is activated. Lacidipine is a new calcium antagonist that is the prototype of the lipophilic dihydropyridines. Of great importance, lacidipine has a slow onset of vasodilator/antihypertensive effect and does not promote an excessive sympathetic drive. These attributes commend its selection as an antihypertensive agent. |
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Authors:
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M Epstein |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Drugs Volume: 57 Suppl 1 ISSN: 0012-6667 ISO Abbreviation: Drugs Publication Date: 1999 |
Date Detail:
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Created Date: 1999-11-17 Completed Date: 1999-11-17 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7600076 Medline TA: Drugs Country: NEW ZEALAND |
Other Details:
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Languages: eng Pagination: 1-10 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Miami School of Medicine, Florida, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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pharmacokinetics,
pharmacology*,
therapeutic use Calcium Channel Blockers / pharmacokinetics, pharmacology*, therapeutic use Dihydropyridines / pharmacokinetics, pharmacology, therapeutic use Humans Hypertension / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Calcium Channel Blockers; 0/Dihydropyridines; 103890-78-4/lacidipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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