| Role of tenecteplase in pulmonary embolism. | |
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MedLine Citation:
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PMID: 20635764 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients presenting with pulmonary embolism (PE) have a wide spectrum of clinical severity. Although, some patients may present with frank hemodynamic collapse and cardiac arrest, others may present with asymptomatic PE that is discovered incidentally during work up of another condition. Fibrinolytic therapy is an option in the treatment of patients with PE. A rational approach to decide whether to indicate fibrinolytic therapy is based on assessment of benefits that each patient will derive from fibrinolytic therapy weighed against risk of major bleeding and intracranial hemmorage. There is a clear benefit/risk ratio for fibrinolytic therapy in patients with PE who present with cardiac arrest and in those who are hemodynamically unstable from a massive pulmonary embolism. With proper risk assessment selected patients with stable hemodynamics and right ventricular dysfunction may also benefit from fibrinolytic therapy. This article sets out to review the literature on tenecteplase in treatment of patients with PE. |
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Authors:
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Sameer Shrivastava; Ankush Sachdeva; Biswajit Paul |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Indian heart journal Volume: 61 ISSN: 0019-4832 ISO Abbreviation: Indian Heart J Publication Date: 2009 Sep-Oct |
Date Detail:
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Created Date: 2010-07-19 Completed Date: 2010-08-06 Revised Date: 2010-12-23 |
Medline Journal Info:
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Nlm Unique ID: 0374675 Medline TA: Indian Heart J Country: India |
Other Details:
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Languages: eng Pagination: 464-6 Citation Subset: IM |
Affiliation:
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Escorts Heart Institute and Research Centre, Okhla, New Delhi, India. sameer_rashmi@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Fibrinolytic Agents
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therapeutic use* Humans Pulmonary Embolism / drug therapy*, physiopathology Randomized Controlled Trials as Topic Risk Assessment Thrombolytic Therapy* Tissue Plasminogen Activator / therapeutic use* Ventricular Function, Right / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; 0/tenecteplase; EC 3.4.21.68/Tissue Plasminogen Activator |
| Comments/Corrections | |
Comment In:
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Indian Heart J. 2010 Jan-Feb;62(1):92 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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