| Role of the sympathetic nervous system in the ischemic and reperfused heart. | |
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MedLine Citation:
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PMID: 8805801 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Norepinephrine, that has been released from sympathetic nerve endings in response to myocardial ischemia, may have either a beneficial or a harmful effect on the ischemic heart. If the duration of ischemia is short, the release of norepinephrine may be favorable for the production of energy and for protection of the heart against ischemic damage. If the duration of ischemia is prolonged, there is a marked increase in number of both alpha 1 and beta-adrenoceptors located in the sarcolemmal membrane, as well as an excessive increase in release of norepinephrine. These events during the prolonged period of ischemia can produce an imbalance between oxygen supply and demand, which is harmful to the heart. The anti-ischemic effect of alpha 1- and beta-adrenoceptor antagonists is not attributed merely to improvement of oxygen balance, but reduction of phospholipase activity or stabilization of membrane may also be important as an underlying mechanism. |
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Authors:
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A Hara; Y Abiko |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: EXS Volume: 76 ISSN: 1023-294X ISO Abbreviation: EXS Publication Date: 1996 |
Date Detail:
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Created Date: 1996-12-10 Completed Date: 1996-12-10 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9204529 Medline TA: EXS Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 285-97 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Asahikawa Medical College, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Antagonists
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pharmacology Adrenergic beta-Antagonists / pharmacology Animals Humans Ischemic Preconditioning, Myocardial Myocardial Ischemia / etiology*, physiopathology, prevention & control Myocardial Reperfusion Injury / etiology*, physiopathology, prevention & control Myocardial Stunning / etiology, physiopathology Norepinephrine / physiology Receptors, Adrenergic, alpha / metabolism Receptors, Adrenergic, beta / metabolism Sympathetic Nervous System / physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Antagonists; 0/Adrenergic beta-Antagonists; 0/Receptors, Adrenergic, alpha; 0/Receptors, Adrenergic, beta; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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