Document Detail

Role of the sympathetic nervous system in the ischemic and reperfused heart.
MedLine Citation:
PMID:  8805801     Owner:  NLM     Status:  MEDLINE    
Norepinephrine, that has been released from sympathetic nerve endings in response to myocardial ischemia, may have either a beneficial or a harmful effect on the ischemic heart. If the duration of ischemia is short, the release of norepinephrine may be favorable for the production of energy and for protection of the heart against ischemic damage. If the duration of ischemia is prolonged, there is a marked increase in number of both alpha 1 and beta-adrenoceptors located in the sarcolemmal membrane, as well as an excessive increase in release of norepinephrine. These events during the prolonged period of ischemia can produce an imbalance between oxygen supply and demand, which is harmful to the heart. The anti-ischemic effect of alpha 1- and beta-adrenoceptor antagonists is not attributed merely to improvement of oxygen balance, but reduction of phospholipase activity or stabilization of membrane may also be important as an underlying mechanism.
A Hara; Y Abiko
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  EXS     Volume:  76     ISSN:  1023-294X     ISO Abbreviation:  EXS     Publication Date:  1996  
Date Detail:
Created Date:  1996-12-10     Completed Date:  1996-12-10     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9204529     Medline TA:  EXS     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  285-97     Citation Subset:  IM    
Department of Pharmacology, Asahikawa Medical College, Japan.
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MeSH Terms
Adrenergic alpha-Antagonists / pharmacology
Adrenergic beta-Antagonists / pharmacology
Ischemic Preconditioning, Myocardial
Myocardial Ischemia / etiology*,  physiopathology,  prevention & control
Myocardial Reperfusion Injury / etiology*,  physiopathology,  prevention & control
Myocardial Stunning / etiology,  physiopathology
Norepinephrine / physiology
Receptors, Adrenergic, alpha / metabolism
Receptors, Adrenergic, beta / metabolism
Sympathetic Nervous System / physiopathology*
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Adrenergic beta-Antagonists; 0/Receptors, Adrenergic, alpha; 0/Receptors, Adrenergic, beta; 51-41-2/Norepinephrine

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